(2S)-1-(4-ethyl-1-phenylhex-1-yn-3-yl)-2-(hydroxymethyl)pyrrolidine

Base Information

• Chemical Name: (2S)-1-(4-ethyl-1-phenylhex-1-yn-3-yl)-2-(hydroxymethyl)pyrrolidine
• CAS No.: 1207762-04-6
• Molecular Formula: C₁₉H₂₇NO
• Molecular Weight: 285.429
• Mol file: 1207762-04-6.mol

Synonyms:(2S)-1-(4-ethyl-1-phenylhex-1-yn-3-yl)-2-(hydroxymethyl)pyrrolidine

Chemical Property of (2S)-1-(4-ethyl-1-phenylhex-1-yn-3-yl)-2-(hydroxymethyl)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (2S)-1-(4-ethyl-1-phenylhex-1-yn-3-yl)-2-(hydroxymethyl)pyrrolidine

There total 1 articles about (2S)-1-(4-ethyl-1-phenylhex-1-yn-3-yl)-2-(hydroxymethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-Ethylbutyraldehyde (97-96-1) + phenylacetylene (536-74-3) + (S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → (2S)-1-(4-ethyl-1-phenylhex-1-yn-3-yl)-2-(hydroxymethyl)pyrrolidine (1207762-04-6)

Guidance literature:

With Cu-MCM-41; In neat (no solvent); at 110 ℃; diastereoselective reaction; Green chemistry;

DOI:10.1016/j.tetlet.2018.05.010

Reference yield:

(2S)-1-(4-ethyl-1-phenylhex-1-yn-3-yl)-2-(hydroxymethyl)pyrrolidine (1207762-04-6) → (R)-(4-ethylhexa-1,2-dien-1-yl)benzene

Guidance literature:

With silver nitrate; In acetonitrile; at 70 ℃; for 0.333333h; enantioselective reaction; Microwave irradiation;

DOI:10.1039/b914516h

upstream raw materials:

2-Ethylbutyraldehyde

phenylacetylene

(S)-1-Pyrrolidin-2-yl-methanol