(5R,7R,8R,9S,10S,13R,14S,17R)-17-[(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one O-benzyl-oxime

Base Information

Chemical Name:(5R,7R,8R,9S,10S,13R,14S,17R)-17-[(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one O-benzyl-oxime
CAS No.:159790-99-5
Molecular Formula:C₄₀H₆₇NO₃Si
Molecular Weight:638.062
Hs Code.:

(5R,7R,8R,9S,10S,13R,14S,17R)-17-[(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one O-benzyl-oxime

Synonyms:(5R,7R,8R,9S,10S,13R,14S,17R)-17-[(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one O-benzyl-oxime

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Chemical Property of (5R,7R,8R,9S,10S,13R,14S,17R)-17-[(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one O-benzyl-oxime

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Technology Process of (5R,7R,8R,9S,10S,13R,14S,17R)-17-[(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one O-benzyl-oxime

There total 10 articles about (5R,7R,8R,9S,10S,13R,14S,17R)-17-[(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one O-benzyl-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 159790-98-4
(5S,7R,8R,9S,10S,13R,14S,17R)-17-[(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one

: 159790-99-5
(5R,7R,8R,9S,10S,13R,14S,17R)-17-[(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one O-benzyl-oxime

Guidance literature:: With pyridine; In ethanol; for 16h; Heating;
DOI:10.1016/0040-4039(94)88254-1

Reference yield:

: 19462-13-6
3β-acetoxy-5-cholenic acid

: 159790-99-5
(5R,7R,8R,9S,10S,13R,14S,17R)-17-[(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one O-benzyl-oxime

Guidance literature:: Multi-step reaction with 10 steps

1: (COCl)2 / CH₂Cl₂ / 2 h / Heating

2: 60 percent / cadmium bromide / benzene / 1 h / Ambient temperature

3: 80 percent / sodium borohydride, calcium chloride / tetrahydrofuran / 5 h / Ambient temperature

4: 90 percent / imidazole / CH₂Cl₂ / 16 h / Ambient temperature

5: 46 percent / chromium hexacarbonyl, tert-butyl hydroperoxide / acetonitrile / 12 h / Heating

6: 81 percent / Li, liq. NH₃ / diethyl ether / 0.17 h / -78 °C

7: 80 percent / K-selectride / tetrahydrofuran / 5 h / -50 °C

8: 88 percent / NaCN / methanol / 8 h / Heating

9: 59 percent / aluminum tri-tert-butoxide, cyclohexanone / toluene / 20 h / 120 °C

10: 97 percent / C₅H₅N / ethanol / 16 h / Heating

With pyridine; 1H-imidazole; tert.-butylhydroperoxide; sodium tetrahydroborate; oxalyl dichloride; sodium cyanide; ammonia; cyclohexanone; lithium; aluminum tri-tert-butoxide; potassium tri-sec-butyl-borohydride; chromium⁽⁰⁾ hexacarbonyl; calcium chloride; cadmium(II) bromide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; toluene; acetonitrile; benzene;
DOI:10.1016/0040-4039(94)88254-1

Reference yield:

: 20981-59-3
3β-acetoxy-cholest-5-en-24-one

: 159790-99-5
(5R,7R,8R,9S,10S,13R,14S,17R)-17-[(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one O-benzyl-oxime

Guidance literature:: Multi-step reaction with 8 steps

1: 80 percent / sodium borohydride, calcium chloride / tetrahydrofuran / 5 h / Ambient temperature

2: 90 percent / imidazole / CH₂Cl₂ / 16 h / Ambient temperature

3: 46 percent / chromium hexacarbonyl, tert-butyl hydroperoxide / acetonitrile / 12 h / Heating

4: 81 percent / Li, liq. NH₃ / diethyl ether / 0.17 h / -78 °C

5: 80 percent / K-selectride / tetrahydrofuran / 5 h / -50 °C

6: 88 percent / NaCN / methanol / 8 h / Heating

7: 59 percent / aluminum tri-tert-butoxide, cyclohexanone / toluene / 20 h / 120 °C

8: 97 percent / C₅H₅N / ethanol / 16 h / Heating

With pyridine; 1H-imidazole; tert.-butylhydroperoxide; sodium tetrahydroborate; sodium cyanide; ammonia; cyclohexanone; lithium; aluminum tri-tert-butoxide; potassium tri-sec-butyl-borohydride; chromium⁽⁰⁾ hexacarbonyl; calcium chloride; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/0040-4039(94)88254-1