N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-methoxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide hydrochloride

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Chemical Name:N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-methoxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide hydrochloride
CAS No.:916483-48-2
Molecular Formula:C₂₂H₂₀F₂N₆O₃*ClH
Molecular Weight:490.897
Hs Code.:

Synonyms:N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-methoxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide hydrochloride

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Chemical Property of N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-methoxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide hydrochloride

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Technology Process of N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-methoxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide hydrochloride

There total 8 articles about N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-methoxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 786681-68-3
2-(4-amino-1H-pyrazol-1-yl)-N-(2,3-difluorophenyl)acetamide

: 895147-53-2
4-chloro-7-ethoxy-5-methoxyquinazoline

: 916483-48-2
N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-methoxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide hydrochloride

Guidance literature:: In isopropyl alcohol; at 90 ℃; for 0.75h;

Reference yield:

: 916483-52-8
2-(4-bromo-1H-pyrazol-1-yl)-N-(2,3-difluorophenyl)acetamide

: 916483-48-2
N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-methoxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.08 h

1.2: 4 h / 90 °C

2.1: hydrogenchloride / water; ethyl acetate / 1.02 h / 20 °C

3.1: sodium hydrogencarbonate / water; ethyl acetate / 1 h

4.1: isopropyl alcohol / 0.75 h / 90 °C

With hydrogenchloride; sodium hydrogencarbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; ethyl acetate; isopropyl alcohol;

Reference yield:

: 916483-51-7
2-chloro-N-(2,3-difluorophenyl)acetamide

: 916483-48-2
N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-methoxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / ISOPROPYLAMIDE / 18 h / 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.08 h

2.2: 4 h / 90 °C

3.1: hydrogenchloride / water; ethyl acetate / 1.02 h / 20 °C

4.1: sodium hydrogencarbonate / water; ethyl acetate / 1 h

5.1: isopropyl alcohol / 0.75 h / 90 °C

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ISOPROPYLAMIDE; water; ethyl acetate; isopropyl alcohol;