(1-methylcyclopropyl)methyl 4-(6-{4-[(methylamino)carbonyl]phenyl}-4H-1,3-benzo-dioxin-2-yl)piperidine-1-carboxylate

Base Information

Chemical Name:(1-methylcyclopropyl)methyl 4-(6-{4-[(methylamino)carbonyl]phenyl}-4H-1,3-benzo-dioxin-2-yl)piperidine-1-carboxylate
CAS No.:1200572-92-4
Molecular Formula:C₂₇H₃₂N₂O₅
Molecular Weight:464.561
Hs Code.:

Synonyms:(1-methylcyclopropyl)methyl 4-(6-{4-[(methylamino)carbonyl]phenyl}-4H-1,3-benzo-dioxin-2-yl)piperidine-1-carboxylate

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Chemical Property of (1-methylcyclopropyl)methyl 4-(6-{4-[(methylamino)carbonyl]phenyl}-4H-1,3-benzo-dioxin-2-yl)piperidine-1-carboxylate

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Technology Process of (1-methylcyclopropyl)methyl 4-(6-{4-[(methylamino)carbonyl]phenyl}-4H-1,3-benzo-dioxin-2-yl)piperidine-1-carboxylate

There total 7 articles about (1-methylcyclopropyl)methyl 4-(6-{4-[(methylamino)carbonyl]phenyl}-4H-1,3-benzo-dioxin-2-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1200575-74-1
4-[2-(1-{[(1-methylcyclopropyl)methoxy]carbonyl}piperidin-4-yl)-4H-1,3-benzo-dioxin-6-yl]benzoic acid

: 74-89-5
methylamine

: 1200572-92-4
(1-methylcyclopropyl)methyl 4-(6-{4-[(methylamino)carbonyl]phenyl}-4H-1,3-benzo-dioxin-2-yl)piperidine-1-carboxylate

Guidance literature:: 4-[2-(1-{[(1-methylcyclopropyl)methoxy]carbonyl}piperidin-4-yl)-4H-1,3-benzo-dioxin-6-yl]benzoic acid; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N,N-dimethyl-formamide; In dimethyl sulfoxide; ethyl acetate; for 0.166667h;

methylamine; With triethylamine; In dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1200576-26-6
benzyl 4-{6-[4-(methoxycarbonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

: 1200572-92-4
(1-methylcyclopropyl)methyl 4-(6-{4-[(methylamino)carbonyl]phenyl}-4H-1,3-benzo-dioxin-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; ethanol / 60 °C

2.1: N,N-dimethyl-formamide; acetonitrile / 0.08 h

2.2: 2 h / 50 °C

3.1: water; potassium hydroxide / tetrahydrofuran; methanol / 1 h / 50 °C

4.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N,N-dimethyl-formamide / dimethyl sulfoxide; ethyl acetate / 0.17 h

With water; hydrogen; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N,N-dimethyl-formamide; potassium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1200575-51-4
benzyl 4-(6-bromo-4H-1,3-benzodioxin-2-yl)piperidine-1-carboxylate

: 1200572-92-4
(1-methylcyclopropyl)methyl 4-(6-{4-[(methylamino)carbonyl]phenyl}-4H-1,3-benzo-dioxin-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C

2.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; ethanol / 60 °C

3.1: N,N-dimethyl-formamide; acetonitrile / 0.08 h

3.2: 2 h / 50 °C

4.1: water; potassium hydroxide / tetrahydrofuran; methanol / 1 h / 50 °C

5.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N,N-dimethyl-formamide / dimethyl sulfoxide; ethyl acetate / 0.17 h

With water; hydrogen; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N,N-dimethyl-formamide; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;