N-[3-(tert-butoxycarbonyl)aminopropyl]-2(R)-(carbobenzoxy)amino-4-methylpentanamide

Base Information

Chemical Name:N-[3-(tert-butoxycarbonyl)aminopropyl]-2(R)-(carbobenzoxy)amino-4-methylpentanamide
CAS No.:294625-15-3
Molecular Formula:C₂₂H₃₅N₃O₅
Molecular Weight:421.537
Hs Code.:

Synonyms:N-[3-(tert-butoxycarbonyl)aminopropyl]-2(R)-(carbobenzoxy)amino-4-methylpentanamide

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Chemical Property of N-[3-(tert-butoxycarbonyl)aminopropyl]-2(R)-(carbobenzoxy)amino-4-methylpentanamide

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Technology Process of N-[3-(tert-butoxycarbonyl)aminopropyl]-2(R)-(carbobenzoxy)amino-4-methylpentanamide

There total 1 articles about N-[3-(tert-butoxycarbonyl)aminopropyl]-2(R)-(carbobenzoxy)amino-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 52235-17-3
2(R)-(carbobenzoxy)amino-4-methylpentanoic acid p-nitrophenyl ester

: 75178-96-0
N-Boc-1,3-diaminopropane

: 294625-15-3
N-[3-(tert-butoxycarbonyl)aminopropyl]-2(R)-(carbobenzoxy)amino-4-methylpentanamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1021/jm990356p

Reference yield:

: 294625-15-3
N-[3-(tert-butoxycarbonyl)aminopropyl]-2(R)-(carbobenzoxy)amino-4-methylpentanamide

: N-[1-(3-amidinobutylpropylcarbamoyl)-3-methyl-1(R)-butyl]-1(S)-phenyl-2(R)-[(8-hydroxy-6(R),11(R)-dimethyl-1,2,5,6-tetrahydro-4H-2(R),6-methanobenzazocin-3-yl)methyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / H₂ / 10percent Pd/C / methanol / 0.75 h / 20 °C / 760.05 Torr

2: HOBt; DCC / dimethylformamide / 48 h / 0 - 5 °C

3: aq. TFA / methoxybenzene / 20 °C

4: 57 percent / DIEA / ethanol / 24 h / 20 °C / pH 10

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; 10percent Pd/C; In methanol; ethanol; methoxybenzene; N,N-dimethyl-formamide; 1: Hydrogenolysis / 2: Acylation / 3: Hydrolysis / 4: amidination;
DOI:10.1021/jm990356p

Reference yield:

: 294625-15-3
N-[3-(tert-butoxycarbonyl)aminopropyl]-2(R)-(carbobenzoxy)amino-4-methylpentanamide

: N-[1-(3-aminopropylcarbamoyl)-3-methyl-1(R)-butyl]-1(S)-phenyl-2(R)-[(8-hydroxy-6(R),11(R)-dimethyl-1,2,5,6-tetrahydro-4H-2(R),6-methanobenzazocin-3-yl)methyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / H₂ / 10percent Pd/C / methanol / 0.75 h / 20 °C / 760.05 Torr

2: HOBt; DCC / dimethylformamide / 48 h / 0 - 5 °C

3: aq. TFA / methoxybenzene / 20 °C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; 10percent Pd/C; In methanol; methoxybenzene; N,N-dimethyl-formamide; 1: Hydrogenolysis / 2: Acylation / 3: Hydrolysis;
DOI:10.1021/jm990356p