N-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanine ethyl ester

Base Information

• Chemical Name: N-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanine ethyl ester
• CAS No.: 398461-02-4
• Molecular Formula: C₅₁H₆₈N₆O₁₁
• Molecular Weight: 941.135
• Mol file: 398461-02-4.mol

Synonyms:N-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanine ethyl ester

Chemical Property of N-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanine ethyl ester

There total 6 articles about N-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

n-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanine (398460-96-3) + 3-[2-amino-6-(3-benzyloxy-2-methyl-4-oxo-4H-pyridin-1-yl)-hexanoylamino]-propionic acid ethyl ester; compound with trifluoro-acetic acid → N-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanine ethyl ester (398461-02-4)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 72h;

DOI:10.3987/COM-01-9338

Reference yield:

3-O-benzylmaltol (61049-69-2) → N-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanine ethyl ester (398461-02-4)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. NaOH / ethanol / 96 h / 20 °C

2: 37 percent / dioxane; H₂O / 56 h / 0 - 20 °C

3: 85 percent / N-methylmorpholine; 1-hydroxybenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 72 h / 20 °C

4: 98 percent / aq. NaOH / methanol / 2 h / 20 °C

5: 78 percent / N-methylmorpholine; 1-hydroxybenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 72 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; ethanol; dichloromethane; water;

DOI:10.3987/COM-01-9338

Reference yield:

L-Lysine hydrochloride (657-27-2,10098-89-2,26124-78-7) → N-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanine ethyl ester (398461-02-4)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. NaOH / ethanol / 96 h / 20 °C

2: 37 percent / dioxane; H₂O / 56 h / 0 - 20 °C

3: 85 percent / N-methylmorpholine; 1-hydroxybenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 72 h / 20 °C

4: 98 percent / aq. NaOH / methanol / 2 h / 20 °C

5: 78 percent / N-methylmorpholine; 1-hydroxybenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 72 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; ethanol; dichloromethane; water;

DOI:10.3987/COM-01-9338

upstream raw materials:

n-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanine

3-O-benzylmaltol

L-Lysine hydrochloride

ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-N-tert-butoxycarbonyl-L-norleucine