4-[(2-fluoro-4-methylphenyl)amino]-7-methoxy-6-[1-(methylsulfonyl)piperidin-4-yl]cinnoline-3-carboxamide

Base Information

Chemical Name:4-[(2-fluoro-4-methylphenyl)amino]-7-methoxy-6-[1-(methylsulfonyl)piperidin-4-yl]cinnoline-3-carboxamide
CAS No.:1041852-98-5
Molecular Formula:C₂₃H₂₆FN₅O₄S
Molecular Weight:487.555
Hs Code.:

Synonyms:4-[(2-fluoro-4-methylphenyl)amino]-7-methoxy-6-[1-(methylsulfonyl)piperidin-4-yl]cinnoline-3-carboxamide

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Chemical Property of 4-[(2-fluoro-4-methylphenyl)amino]-7-methoxy-6-[1-(methylsulfonyl)piperidin-4-yl]cinnoline-3-carboxamide

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Technology Process of 4-[(2-fluoro-4-methylphenyl)amino]-7-methoxy-6-[1-(methylsulfonyl)piperidin-4-yl]cinnoline-3-carboxamide

There total 8 articles about 4-[(2-fluoro-4-methylphenyl)amino]-7-methoxy-6-[1-(methylsulfonyl)piperidin-4-yl]cinnoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1041852-99-6
4-(2-fluoro-4-methylphenylamino)-7-methoxy-6-(piperidin-4-yl)cinnoline-3-carboxamide

: 124-63-0
methanesulfonyl chloride

: 1041852-98-5
4-[(2-fluoro-4-methylphenyl)amino]-7-methoxy-6-[1-(methylsulfonyl)piperidin-4-yl]cinnoline-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; for 1h;

Reference yield:

: 1041853-18-2
4-amino-6-bromo-7-methoxycinnoline-3-carboxamide

: 1041852-98-5
4-[(2-fluoro-4-methylphenyl)amino]-7-methoxy-6-[1-(methylsulfonyl)piperidin-4-yl]cinnoline-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / ethanol; water / 216 h / Reflux

1.2: pH ~ 3

2.1: thionyl chloride / N,N-dimethyl-formamide / 4 h / Reflux

2.2: 0 °C

3.1: acetic acid / ethanol / 1 h / 80 °C

4.1: potassium phosphate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / water; butan-1-ol / 100 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 16 h

6.1: hydrogen / hydrogenchloride; 20 % Pd(OH)2/C / methanol / 7500.75 Torr

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 1 h

With potassium phosphate; thionyl chloride; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20 % Pd(OH)2/C; N,N-dimethyl-formamide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1041853-24-0
6-bromo-4-chloro-7-methoxycinnoline-3-carboxamide

: 1041852-98-5
4-[(2-fluoro-4-methylphenyl)amino]-7-methoxy-6-[1-(methylsulfonyl)piperidin-4-yl]cinnoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / ethanol / 1 h / 80 °C

2: potassium phosphate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / water; butan-1-ol / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 16 h

4: hydrogen / hydrogenchloride; 20 % Pd(OH)2/C / methanol / 7500.75 Torr

5: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 1 h

With potassium phosphate; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20 % Pd(OH)2/C; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;