1,8-Dihydroxy-10-[methoxy(4-methylphenyl)methyl]-9(10H)-anthracenone

Base Information

• Chemical Name: 1,8-Dihydroxy-10-[methoxy(4-methylphenyl)methyl]-9(10H)-anthracenone
• CAS No.: 151562-80-0
• Molecular Formula: C₂₃H₂₀O₄
• Molecular Weight: 360.409
• Mol file: 151562-80-0.mol

Synonyms:1,8-Dihydroxy-10-[methoxy(4-methylphenyl)methyl]-9(10H)-anthracenone

Chemical Property of 1,8-Dihydroxy-10-[methoxy(4-methylphenyl)methyl]-9(10H)-anthracenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,8-Dihydroxy-10-[methoxy(4-methylphenyl)methyl]-9(10H)-anthracenone

There total 3 articles about 1,8-Dihydroxy-10-[methoxy(4-methylphenyl)methyl]-9(10H)-anthracenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,8-dihydroxy-9(10H)-anthracenone (1143-38-0) + (α-chloro-4-methyl-benzyl)-methyl ether (56377-70-9) → 1,8-Dihydroxy-10-[methoxy(4-methylphenyl)methyl]-9(10H)-anthracenone (151562-80-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 0.5h; Yield given;

DOI:10.1021/jm00077a015

Reference yield:

4-methylbenzaldehyde dimethylacetal (3395-83-3) → 1,8-Dihydroxy-10-[methoxy(4-methylphenyl)methyl]-9(10H)-anthracenone (151562-80-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetyl chloride, thionyl chloride / 50 - 60 °C

2: 1,8-diazabicyclo<5.4.0>undec-7-ene / CH₂Cl₂ / 0.5 h / 0 °C

With thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; acetyl chloride; In dichloromethane;

DOI:10.1021/jm00077a015

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 1,8-Dihydroxy-10-[methoxy(4-methylphenyl)methyl]-9(10H)-anthracenone (151562-80-0)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄ / methanol

2: acetyl chloride, thionyl chloride / 50 - 60 °C

3: 1,8-diazabicyclo<5.4.0>undec-7-ene / CH₂Cl₂ / 0.5 h / 0 °C

With thionyl chloride; sulfuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; acetyl chloride; In methanol; dichloromethane;

DOI:10.1021/jm00077a015

upstream raw materials:

1,8-dihydroxy-9(10H)-anthracenone

(α-chloro-4-methyl-benzyl)-methyl ether

4-methylbenzaldehyde dimethylacetal

4-methyl-benzaldehyde