4'-(Dimethylamino)acetophenone (E)-oxime

Base Information

• Chemical Name: 4'-(Dimethylamino)acetophenone (E)-oxime
• CAS No.: 6310-87-8
• Molecular Formula: C10H14N2O
• Molecular Weight: 178.234
• NSC Number: 43967
• Nikkaji Number: J918.922J
• Mol file: 6310-87-8.mol

Synonyms:6310-87-8;NSC43967;NSC-43967;4'-(Dimethylamino)acetophenone (E)-oxime;4-[1-(hydroxyimino)ethyl]-N,N-dimethylaniline

Chemical Property of 4'-(Dimethylamino)acetophenone (E)-oxime

Chemical Property:

• Vapor Pressure: 0.000193mmHg at 25°C
• Boiling Point: 314.8°C at 760 mmHg
• Flash Point: 144.2°C
• Density: 1.01g/cm³
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 178.110613074
• Heavy Atom Count: 13
• Complexity: 181

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=NO)C1=CC=C(C=C1)N(C)C
• Isomeric SMILES: C/C(=N/O)/C1=CC=C(C=C1)N(C)C

Technology Process of 4'-(Dimethylamino)acetophenone (E)-oxime

There total 1 articles about 4'-(Dimethylamino)acetophenone (E)-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-dimethylaminoacetophenone (2124-31-4) → p-dimethylaminoacetophenone oxime (6310-87-8)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; for 12h; Heating;

Reference yield: 97.0%

p-dimethylaminoacetophenone oxime (6310-87-8) + trimethyltin(IV) hydroxide (56-24-6) → (CH3)3SnONC(CH3)C6H4N(CH3)2

Guidance literature:

In benzene; byproducts: H2O; mixing tin-compd. and oxime in anhyd. benzene under exclusion of moisture, refluxing; removal of water azeotropically (azeotropic dehydration technique on the Dean-Stark assembly), removal of excess benzene by distn. under reduced pressure, elem. anal.;

Reference yield: 72.0%

1-azidostyrene (16717-64-9) + p-dimethylaminoacetophenone oxime (6310-87-8) → N,N,1-trimethyl-3-phenylisoquinolin-6-amine

Guidance literature:

With palladium diacetate; In toluene; at 90 ℃; for 8h; Sealed tube;

DOI:10.1021/acs.joc.5b02376

upstream raw materials:

4'-dimethylaminoacetophenone

Downstream raw materials:

2-phenyl-1H-pyrrole

2-phenyl-1-vinyl-1H-pyrrole

4-(1-aminoethyl)-N,N-dimethylaniline

[3-(4-Dimethylamino-phenyl)-5-hydroxy-4,5-dihydro-isoxazol-5-yl]-acetic acid ethyl ester

Refernces

• 1、 Kaewchangwat, Narongpol,Sukato, Rangsarit,Vchirawongkwin, Viwat,Vilaivan, Tirayut,Sukwattanasinitt, Mongkol,Wacharasindhu, Sumrit. "Direct synthesis of aryl substituted pyrroles from calcium carbide: An underestimated chemical feedstock?". . p. 460 - 465. Retrieved 2018/04/16.