56-24-6

Basic information

• Product Name: TRIMETHYLTIN HYDROXIDE
• Synonyms: trimethylstannylhydroxide;trimethyl-tihydroxide;TIN TRIMETHYL HYDROXIDE;Trimethyltinhydroxide,98%;STANNANE,HYDROXYTRIMETHYL-;Hydroxytrimethyltin(IV);Trimethylstannyl alcohol;Trimethyltin hydroxide, 98% (CH3)3SnOH F.W.180.80
• CAS NO: 56-24-6
• Molecular Formula: C₃H₁₀OSn
• Molecular Weight: 180.82
• Product Categories: organotin compound
• Mol File: 56-24-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 118°C
• Boiling Point: 80°C
• Flash Point: 26℃
• Appearance: White/Powder
• Density: g/cm³
• PKA: 6.36±0.70(Predicted)
• Water Solubility: Soluble in water.
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: TRIMETHYLTIN HYDROXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIMETHYLTIN HYDROXIDE(56-24-6)
• EPA Substance Registry System: TRIMETHYLTIN HYDROXIDE(56-24-6)

Safety Data

• Hazard Codes: T+:Very toxic
• Statements: 20/21/22
• Safety Statements: 22-36/37/39-45
• RIDADR: 3146
• RTECS: WH8400000
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 56-24-6(Hazardous Substances Data)

Usage

Chemical Properties

Colorless, white crystals. Soluble in water and many organic solvents.

Uses

Different sources of media describe the Uses of 56-24-6 differently. You can refer to the following data:
1. Drug.
2. Trimethyltin hydroxide is used in the synthesis of modified thymines, which is useful as inhibitors of RNase A. It is also used in the preparation of ketoheterocycle inhibitors of fatty acid amide inhibitors. It reacts with 2,2-disubstituted benzothiazolines to form trialkyltin derivatives of sulphur containing Schiff base complexes.

Hazard

A poison.

InChI:InChI=1/3CH3.H2O.Sn/h3*1H3;1H2;/rC3H9Sn.H2O/c1-4(2)3;/h1-3H3;1H2

Synthetic route

(CH3)3SnCH2C6H4-m-Cl (27640-06-8) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With sodium hydroxide In ethanol; water byproducts: m-chlorotoluene; refluxing for 52 h;;	85%
With NaOH In ethanol; water byproducts: m-chlorotoluene; refluxing for 52 h;;	85%
In methanol; deuteromethanol byproducts: m-chlorotoluene; alkaline decompn. at 50°C;;
In methanol; deuteromethanol byproducts: m-chlorotoluene; alkaline decompn. at 50°C;;

bis(trimethyltin)oxide (1692-18-8) + acetylene (74-86-2) → trimethylstannylacetylene (1112-00-1) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
at 8-12 atm in a sealed tube;;	A 65.5% B n/a

2,6-dichloro-1,4-benzoquinone (697-91-6) + hexamethyldistannane (661-69-8) → C6Cl2H2(OSn(CH3)3)2 (76279-09-9) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
In benzene keeping at room temp. (N2) for 4 d; various yields in various conditions; evapn.; elem. anal.;	A 63% B n/a

tris(trimethylstannyl)stibine (7029-29-0) → bis(trimethyltin)oxide (1692-18-8) + tetrakis(trimethylstannyl)distibane (68354-51-8) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With oxygen In neat (no solvent) stibane left in air for 3 d; suspending in Ar-satd. acetone, decanting, recrystn. of red residue from toluene (2nd and 3rd product isolated from acetone suspn.); elem. anal.;	A n/a B 47% C n/a

trimethyl(trimethylstannyl)silane (16393-88-7) → Hexamethyldisiloxane (107-46-0) + hexamethyldistannane (661-69-8) + trimethylstannane (1631-73-8) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With bromobenzene; calcium In water for 1h; Ambient temperature; Further byproducts given;	A 36% B 8% C 42% D 10%

trimethyl(trimethylstannyl)silane (16393-88-7) → Hexamethyldisiloxane (107-46-0) + trimethyl(phenyl)stannane (934-56-5) + hexamethyldistannane (661-69-8) + trimethylstannane (1631-73-8) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With bromobenzene; water; calcium In gas Ca vaporized at 900°C in vac. (ca. 5E-3 Torr), Me3SiSnMe3 introduced as vapor, mixed vapor condensed on cold (77 K) walls, warmed to room temp., excess of C6H5Br admitted as vapor, left to stand for 1 h, hydrolyzed with water; org. layer extd. with ether, products identified by GC-MASS, GLC;	A 36% B 2% C 8% D 42% E 10%

trimethyltin bromide (1066-44-0) → tin (7440-31-5) + tetramethylstannane (594-27-4) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With zinc In water
With Zn In water

(pentafluorophenyl)trimethyltin (1015-53-8) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With F(1-) or Cl(1-) or CN(1-) In water byproducts: C6F5H;
With F(1-) or Cl(1-) or CN(1-) In ethanol; water byproducts: C6F5H;
With NaF or NaOH In water byproducts: C6HF5;

2-(trimethylstannyl)-1-methylimidazole (86108-56-7) → 1-methyl-1H-imidazole (616-47-7) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With water

((methyl)3tin)2C(CON(methyl)2)2 (108202-42-2) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With water byproducts: N,N,N',N'-tetramethylmalondiamide; hydrolysis;

trimethyl(trimethylstannyl)silane (16393-88-7) → Hexamethyldisiloxane (107-46-0) + hexamethyldistannane (661-69-8) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With bromobenzene; water In gas Me3SiSnMe3 vapor condensed on cold (77 K) walls, warmed to room temp., excess of C6H5Br admitted as vapor, left to stand for 1 h, hydrolyzed with water; org. layer extd. with ether, products identified by GC-MASS, GLC;

trichloromethyl-trimethyl tin (13340-12-0) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With water In water byproducts: CHCl3;
With H2O In water byproducts: CHCl3;

benzyl(trimethyl)tin (4314-94-7) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
In dimethyl sulfoxide byproducts: toluene; alkaline decompn.; mechanism discussed;;
In methanol byproducts: toluene; alkaline decompn.; mechanism discussed;;
In methanol; deuteromethanol Kinetics; byproducts: toluene; at 50°C; mechanism discussed;;

1-(trimethylstannyl)naphthalene (944-85-4) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With water In methanol; water Kinetics; byproducts: C10H8; Irradiation (UV/VIS); decompn. in 95% aq. methanol on influence of light; mechanism discussed;;
In methanol byproducts: C10H8; alkaline decompn. in methanol;;
In methanol byproducts: C10H8; alkaline decompn. in methanol;;
With H2O In methanol; water Kinetics; byproducts: C10H8; Irradiation (UV/VIS); decompn. in 95% aq. methanol on influence of light; mechanism discussed;;

methanol (67-56-1) + 1-(trimethylstannyl)-1,12-dicarba-closo-dodecaborane (51375-18-9) + potassium hydroxide → 1,12-dicarbora-closo-dodecaborane (20644-12-6) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
In methanol Kinetics; hydrolysis;;
In methanol

methanol (67-56-1) + (CH3)3Sn-1,7-B10C2H11 (36534-54-0) + potassium hydroxide → 1,7-dicarba-closo-dodecaborane(12) (16986-24-6) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
In methanol Kinetics; hydrolysis;;
In methanol

methanol (67-56-1) + (CH3)3Sn-1,2-B10C2H11 (51375-19-0) + potassium hydroxide → 1,2-dicarba-closo-dodecaborane(12) (16872-09-6) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
In methanol Kinetics; hydrolysis;;
In methanol

propan-1-ol (71-23-8) + dichloromethyl-trimethyl tin (21905-04-4) → trimethyl-propoxytin (38047-38-0) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With ammonia; water; ammonium chloride Kinetics; byproducts: CH2Cl2; Sn compd. placed into n-propanol-water in the presence of ammonia buffer (NH3/NH4Cl) at 25°C; products not isolated, determined by GLC;

propan-1-ol (71-23-8) + trimethyl(dibromomethyl)stanne (23895-50-3) → trimethyl-propoxytin (38047-38-0) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With ammonia; water; ammonium chloride Kinetics; byproducts: CH2Br2; Sn compd. placed into n-propanol-water in the presence of ammonia buffer (NH3/NH4Cl) at 25°C; products not isolated, determined by GLC;

2-trimethylstannylpyridine (13737-05-8) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With water In water byproducts: C5H5N;
With H2O In water byproducts: C5H5N;

1-trimethylstannyl-2-trifluoromethyl-3,3-difluoro-1-cyclopropene (19097-33-7) → 2,2-difluoro-trifluoromethyl-cyclopropene (19097-36-0) + trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
20 °C, hydrolysis;;
20 °C, hydrolysis;;

1-(trimethylstannyl)-1,12-dicarba-closo-dodecaborane (51375-18-9) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With potassium hydroxide In methanol Kinetics; byproducts: 1,12-B10C2H12;
With KOH In methanol Kinetics; byproducts: 1,12-B10C2H12;

(CH3)3Sn-1,7-B10C2H11 (36534-54-0) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With potassium hydroxide In methanol Kinetics; byproducts: 1,7-B10C2H12;
With KOH In methanol Kinetics; byproducts: 1,7-B10C2H12;

(CH3)3Sn-1,2-B10C2H11 (51375-19-0) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With potassium hydroxide In methanol Kinetics; byproducts: 1,2-B10C2H12;
With KOH In methanol Kinetics; byproducts: 1,2-B10C2H12;

Trimethyl-(brom-dichlor-methyl)-stannan (13340-29-9) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With water In water byproducts: CHBrCl2; hydrolysis;;
With H2O In water byproducts: CHBrCl2; hydrolysis;;

Trimethyl-tribrom-methylstannan (13340-13-1) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With water In water byproducts: CHBr3; hydrolysis;;
With H2O In water byproducts: CHBr3; hydrolysis;;

N,N-Dimethylacetamidohomotrimethylstannan (997-36-4) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With H2O In water byproducts: CH3CON(CH3)2;

Trimethyl--stannan (74862-50-3) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With H2O byproducts: CH2CHCCH;

(CH3)3SnCH2C6H4-p-Br (20364-23-2) → trimethyltin(IV) hydroxide (56-24-6)

Conditions	Yield
With sodium hydroxide In methanol Kinetics; byproducts: p-bromotoluene;
With NaOH In methanol Kinetics; byproducts: p-bromotoluene;

N-{(triethylstannyloxysulphonyl)maleoyl}amino acetic acid (135532-17-1) + trimethyltin(IV) hydroxide (56-24-6) → trimethyltin N-{(triethylstannyloxysulphonyl)maleoyl}amino acetate (135532-21-7, 135532-19-3)

Conditions	Yield
In ethanol addn. of Me3SnOH to a soln. of the other Sn compound in ethyl alcohol; heated for 3 h at 90°C;; removal of solvent by distn.; kept in vac. at 90°C for 2-3 h; elem. anal.;;	99%

N-acetyl-DL-methionine (1115-47-5) + trimethyltin(IV) hydroxide (56-24-6) → SnMe3(AcMetO)

Conditions	Yield
In methanol soln. AcMet in methanol added to soln. SnMe3(OH) in methanol and stirred overnight or refluxed for 2 h; solvent evapd., diethyl ether and light petroleum (b.p. 40-60°C)added and mixt. kept in freezer, crystals washed and dried in vacuo; elem. anal.;	99%

di-tert-butylzinc (16636-96-7) + trimethyltin(IV) hydroxide (56-24-6) → [Me3SnOZntBu]4

Conditions	Yield
In toluene at -78 - 20℃; Schlenk technique;	99%

methyl 4-(4-((E)-(4-(2-(3,5-bis(((S)-3,7-dimethyloctyl)carbamoyl)benzamido)ethoxy)phenyl)diazenyl)phenoxy)butanoate + trimethyltin(IV) hydroxide (56-24-6) → 4-(4-((E)-(4-(2-(3,5-bis(((S)-3,7-dimethyloctyl)carbamoyl)benzamido)ethoxy)phenyl)diazenyl)phenoxy)butanoic acid

Conditions	Yield
In 1,2-dichloro-ethane at 70℃; for 24h;	98%

p-dimethylaminoacetophenone oxime (6310-87-8) + trimethyltin(IV) hydroxide (56-24-6) → (CH3)3SnONC(CH3)C6H4N(CH3)2

Conditions	Yield
In benzene byproducts: H2O; mixing tin-compd. and oxime in anhyd. benzene under exclusion of moisture, refluxing; removal of water azeotropically (azeotropic dehydration technique on the Dean-Stark assembly), removal of excess benzene by distn. under reduced pressure, elem. anal.;	97%

N-{(tributylstannyloxysulphonyl)maleoyl}amino acetic acid (135532-18-2) + trimethyltin(IV) hydroxide (56-24-6) → trimethyltin N-{(tributylstannyloxysulphonyl)maleoyl}amino acetate (135532-22-8, 135532-20-6)

Conditions	Yield
In ethanol addn. of Me3SnOH to a soln. of the other Sn compound in ethyl alcohol; heated for 3 h at 90°C;; removal of solvent by distn.; kept in vac. at 90°C for 2-3 h; elem. anal.;;	96%

N-phenylbenzamidoxime (3488-57-1) + trimethyltin(IV) hydroxide (56-24-6) → Sn(CH3)3ONC(C6H5)NH(C6H5)

Conditions	Yield
In benzene Sn compd. and org. compd. (molar ratio 1:1) refluxed in benzene for 4 htill no more water distilled out azeotropically; distn., addn. of hexane, drying in vac. at 28°C and 0.1 mm for 2h; elem. anal.;	96%

N-(3-methylphenyl)-benzylamine oxime (36954-12-8) + trimethyltin(IV) hydroxide (56-24-6) → Sn(CH3)3ONC(C6H5)NH(C6H4CH3)

Conditions	Yield
In benzene Sn compd. and org. compd. (molar ratio 1:1) refluxed in benzene for 5 htill no more water distilled out azeotropically; distn., addn. of hexane, drying in vac. at 28°C and 0.1 mm for 2h; elem. anal.;	95%

trimethyltin(IV) hydroxide (56-24-6) + 2-benzylideneamino-benzoic acid (5766-76-7) → (N-benzalanthranilato)trimethyltin(IV) (99083-70-2)

Conditions	Yield
In benzene byproducts: H2O; react. under anhydrous conditions, addn. of Me3SnOH to N-benzalanthranilic acid in benzene, refluxing; removal of liberated water azeotropically with benzene at 69°C, elem. anal.;	94%

trimethyltin(IV) hydroxide (56-24-6) + 2-hydroxyethanethiol (60-24-2) → (CH3)3SnSCH2CH2OH (71227-83-3)

Conditions	Yield
In chloroform byproducts: H2O; treatment of Me3SnOH with equimolar amt. of thiol until dissoln. (roomtemp.); drying (Na2SO4), partial evapn. (reduced pressure, 10°C), addn. of petroleum ether, cooling (refrigerator, overnight), washing (petroleum ether/Et2O=1:1), drying (vac., 10°C); elem. anal.;	94%

2,3-dibromomaleimide (1122-10-7) + trimethyltin(IV) hydroxide (56-24-6) → 2,3-dibromo-N-(trimethylstannyl)maleimide (79430-49-2)

Conditions	Yield
In not given byproducts: H2O; solvent toluene or heptane; azeotropic removal water and solvent, recrystn.; elem. anal.;	94%

boric acid (11113-50-1) + trimethyltin(IV) hydroxide (56-24-6) → ((CH3)3SnO)3B3O3 (252228-36-7)

Conditions	Yield
In toluene byproducts: water; N2-atmosphere; stoich. amts., refluxing for 20 h (distn. off of water); evapn. (reduced pressure), dissoln. in Et2O, filtration, evapn. (vac.); elem. anal.;	94%

N-{(4-triethylstannyloxysulphonyl)phthaloyl}amino acetic acid (135532-24-0) + trimethyltin(IV) hydroxide (56-24-6) → trimethyltin N-{(4-triethylstannyloxysulphonyl)phthaloyl}amino acetate (135532-28-4, 135532-26-2)

Conditions	Yield
In ethanol addn. of Me3SnOH to a soln. of the other Sn compound in ethyl alcohol; heated for 3 h at 90°C;; removal of solvent by distn.; kept in vac. at 90°C for 2-3 h; elem. anal.;;	92%

dithio terephthalic acid (1076-98-8) + trimethyltin(IV) hydroxide (56-24-6) → (CH3)3SnSOCC6H4COSSn(CH3)3 (119305-90-7)

Conditions	Yield
In methanol (N2); soln. of metal compd. in dry MeOH was added to MeOH soln. of acid (2:1 mol) over a period of 15 min.; after stirring for 1 h mixt. was dried in vac.; residue suspd. in warm MeOH, filtered and dried in vac. over silicagel; stored at 0°C in total darkness; elem. anal.;	91%

N-{(4-tributylstannyloxysulphonyl)phthaloyl}amino acetic acid (135532-25-1) + trimethyltin(IV) hydroxide (56-24-6) → trimethyltin N-{(4-tributylstannyloxysulphonyl)phthaloyl}amino acetate (135532-29-5, 135532-27-3)

Conditions	Yield
In ethanol addn. of Me3SnOH to a soln. of the other Sn-compound in ethyl alcohol; heated for 3 h at 90°C;; removal of solvent by distn.; kept in vac. at 90°C for 2-3 h; elem. anal.;;	91%

HONC(CH3)(NH2)C6H5 + trimethyltin(IV) hydroxide (56-24-6) → (CH3)3SnONC(CH3)C6H4NH2 (75270-65-4)

Conditions	Yield
In benzene byproducts: H2O; mixing tin-compd. and oxime together in benzene under exclusion of moisture, refluxing; removal of water azeotropically (azeotropic dehydration technique on the Dean-Stark assembly), removal of excess solvent by distn. under reduced pressure, elem. anal.;	91%

2-Methoxybenzoic acid (579-75-9) + trimethyltin(IV) hydroxide (56-24-6) → trimethyltin 2-methoxybenzoate

Conditions	Yield
In benzene byproducts: H2O; addn. of o-anisic acid to a suspension of the Sn-compd. in benzene, heating under reflux for 4 h with a Dean-Stark separator; removing of solvent, recrystn. from CH2Cl2/Skelly mixt.; elem. anal.;	90.2%

tributylstannyloxysulphonylmaleic anhydride (128381-81-7) + trimethyltin(IV) hydroxide (56-24-6) → bis-trimethyltin(tributylstannyloxysulphonyl)maleate (135532-10-4)

Conditions	Yield
In acetonitrile dropwise addn. of a soln. of trimethyltin hydroxide to a soln. of the other Sn compound in acetonitrile; stirring for 2-3 h at 90°C;; removal of solvent to dryness; purified in boiling alcohol with activated carbon; pptn.; elem. anal.;;	90%

thioacetylacetone (14660-20-9) + trimethyltin(IV) hydroxide (56-24-6) → (CH3)3Sn(CH3CSCHCOCH3) (84902-71-6)

Conditions	Yield
In chloroform slow heating of Sn-compd. and diketone in chloroform under reflux for 4-8 h, continuous fractionating out formed water during this period; removal of solvent at 35-40°C/2 mm, elem. anal.;	90%
In benzene slow heating of Sn-compd. and diketone in benzene under reflux for 4-8 h, continuous fractionating out formed water during this period; removal of solvent at 35-40°C/2 mm, elem. anal.;	90%

N-phthaloylglycine (4702-13-0) + trimethyltin(IV) hydroxide (56-24-6) → C6H4(CO)2NCH2COOSn(CH3)3 (139257-15-1)

Conditions	Yield
In toluene byproducts: H2O; refluxed 15 min; toluene-water azeotrope fractionated out, solvent distd. off, residue evapd. in vacuo to dryness, recrystd. from toluene, elem. anal.;	90%

2-(2,5-dioxopyrrolidin-1-yl)acetic acid (5626-41-5) + trimethyltin(IV) hydroxide (56-24-6) → (CH2)2(CO)2NCH2COOSn(CH3)3 (139257-43-5)

Conditions	Yield
In toluene byproducts: H2O; refluxed 15 min; toluene-water azeotrope fractionated out, solvent distd. off, residue evapd. in vacuo to dryness, recrystd. from toluene/heptane, elem. anal.;	90%

2-methyl-2-phthalimidopropanoic acid (14463-79-7) + trimethyltin(IV) hydroxide (56-24-6) → C6H4(CO)2NC(CH3)2COOSn(CH3)3 (139257-24-2)

Conditions	Yield
In toluene byproducts: H2O; refluxed 15 min; toluene-water azeotrope fractionated out, solvent distd. off, residue evapd. in vacuo to dryness, recrystd. from toluene/heptane, elem. anal.;	90%

1-(3-aminophenyl)ethanone oxime (6011-18-3) + trimethyltin(IV) hydroxide (56-24-6) → (CH3)3SnONC(CH3)C6H4NH2 (75270-66-5)

Conditions	Yield
In benzene byproducts: H2O; mixing tin-compd. and oxime together in benzene under exclusion of moisture, refluxing; removal of water azeotropically (azeotropic dehydration technique on the Dean-Stark assembly), removal of excess solvent by distn. under reduced pressure, elem. anal.;	90%

p-aminoacetophenone oxime (38063-81-9) + trimethyltin(IV) hydroxide (56-24-6) → (CH3)3SnONC(CH3)C6H4NH2 (75270-69-8)

Conditions	Yield
In benzene byproducts: H2O; mixing tin-compd. and oxime in anhyd. benzene under exclusion of moisture, refluxing; removal of water azeotropically (azeotropic dehydration technique on the Dean-Stark assembly), removal of excess benzene by distn. under reduced pressure, elem. anal.;	90%

4-Ketopimelic acid (502-50-1) + trimethyltin(IV) hydroxide (56-24-6) → bis(trimethyltin)-4-oxoheptanedioate

Conditions	Yield
In toluene 4-ketopimelic acid and Me3SnOH were refluxed in toluene for 2 h at 125°C; filtered; elem. anal.;	90%

trimethylstannyloxysulphonylmaleic anhydride (128381-79-3) + trimethyltin(IV) hydroxide (56-24-6) → bis-trimethyltin(trimethylstannyloxysulphonyl)maleate (135532-04-6)

Conditions	Yield
In acetonitrile dropwise addn. of a soln. of trimethyltin hydroxide to a soln. of the other Sn compound in acetonitrile; stirring for 2-3 h at 90°C;; removal of solvent to dryness; purified in boiling alcohol with activated carbon; pptn.; elem. anal.;;	88%

triethylstannyloxysulphonylmaleic anhydride (128381-80-6) + trimethyltin(IV) hydroxide (56-24-6) → bis-trimethyltin(triethylstannyloxysulphonyl)maleate (135532-07-9)

Conditions	Yield
In acetonitrile dropwise addn. of a soln. of trimethyltin hydroxide to a soln. of the other Sn compound in acetonitrile; stirring for 2-3 h at 90°C;; removal of solvent to dryness; purified in boiling alcohol with activated carbon; pptn.; elem. anal.;;	88%

trimethyltin(IV) hydroxide (56-24-6) + 2,2'-bis-(1,2-dihydro-4-oxo-3,1-benzoxazine) (24978-39-0) → {(CH3)3SnOOCC6H4NCH}2

Conditions	Yield
In benzene byproducts: H2O; in refluxing benzene; H2O was removed as azeotrope of benzene; elem. anal.;	88%

rac-3-sulfanylpropane-1,2-diol (96-27-5) + trimethyltin(IV) hydroxide (56-24-6) → (CH3)3SnSCH2CHOHCH2OH (78899-70-4)

Conditions	Yield
In chloroform byproducts: H2O; treatment of Me3SnOH with equimolar amt. of thiol until dissoln. (roomtemp.); drying (Na2SO4), partial evapn. (reduced pressure, 10°C), addn. of petroleum ether, cooling (refrigerator, overnight), washing (petroleum ether/Et2O=1:1), drying (vac., 10°C); elem. anal.;	88%

4-chloro-1,3-benzenedithiol (58593-78-5) + trimethyltin(IV) hydroxide (56-24-6) → ((CH3)3Sn)2C6H3ClS2 (95151-66-9)

Conditions	Yield
In methanol addn. of soln. of dithiol in methanol to a suspension of corresponding tin(IV) compd. in methanol; 2h, pptn.;; recrystn. ppt. from CHCl3; elem. anal.;;	87%

Upstream product

• 86108-56-7 2-(trimethylstannyl)-1-methylimidazole 
• 16393-88-7 trimethyl(trimethylstannyl)silane 
• 13340-12-0 trichloromethyl-trimethyl tin 
• 13737-05-8 2-trimethylstannylpyridine 
• 36534-54-0 (CH₃)3Sn-1,7-B₁₀C₂H₁₁ 
• 51375-19-0 (CH₃)3Sn-1,2-B₁₀C₂H₁₁ 
• 697-91-6 2,6-dichloro-1,4-benzoquinone 
• 661-69-8 hexamethyldistannane 
• 17848-35-0 Pentachlorphenyl-trimethylstannan 
• 14064-16-5 <4-(Dimethylamino)phenyl>trimethylstannan 
• 27640-06-8 (CH₃)3SnCH₂C₆H₄-m-Cl 
• 19962-43-7 (CH₃)3SnCH₂C₆H₄-m-CH₃ 
• 41037-63-2 (CH₃)3SnCH₂C₆H₄-p-Cl 
• 19962-42-6 (CH₃)3SnCH₂C₆H₄-p-CH₃ 

Downstream Products

• 594-27-4 tetramethylstannane 
• 7067-50-7 Trimethylzinnisocyanat 
• 1060673-77-9 C₂₁H₂₆O₃ 
• 1070505-67-7 3,4,5,6-tetrachlorophenyl-1,2-dicrboxylatobis[trimethyltin(IV)] 
• 102539-24-2 2-hydroxybenzoatotrimethyltin(IV) 
• 904926-86-9 trimethyltin p-vinylbenzoate 
• 169828-88-0 phenyl-bis(trimethylstannoxy)stibane 
• 244269-07-6 (CH₃)3Sn(C₁₇H₁₁ClNO₂S)*H₂O 
• 252228-36-7 ((CH₃)3SnO)3B₃O₃ 
• 73539-06-7 trimethyltin N-phenyl-N-tosylhydroxylamine 

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