(R)-3-chloro-N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)propane-1-sulfonamide

Base Information

Chemical Name:(R)-3-chloro-N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)propane-1-sulfonamide
CAS No.:1380335-93-2
Molecular Formula:C₁₈H₂₈ClNO₄S
Molecular Weight:389.944
Hs Code.:

Synonyms:(R)-3-chloro-N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)propane-1-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-chloro-N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)propane-1-sulfonamide

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Technology Process of (R)-3-chloro-N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)propane-1-sulfonamide

There total 3 articles about (R)-3-chloro-N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1380335-90-9
(R)-3-chloro-N-(1-(3-(cyclopentyloxy)phenyl)ethyl)propane-1-sulfonamide

: 107-30-2
chloromethyl methyl ether

: 1380335-93-2
(R)-3-chloro-N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)propane-1-sulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 - 45 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm300416h

Reference yield:

: 1309653-53-9
(S)-N-((R)-1-(3-(cyclopentyloxy)phenyl)ethyl)-2-methylpropane-2-sulfinamide

: 1380335-93-2
(R)-3-chloro-N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 - 45 °C / Inert atmosphere

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm300416h

Reference yield:

: 1198223-03-8
(R)-1-(3-(cyclopentyloxy)phenyl)ethan-1-amine hydrochloride

: 1380335-93-2
(R)-3-chloro-N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-N-(methoxymethyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 - 45 °C / Inert atmosphere

With triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm300416h