3-[1-((tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl]prop-2-yn-1-ol

Base Information

• Chemical Name: 3-[1-((tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl]prop-2-yn-1-ol
• CAS No.: 119053-78-0
• Molecular Formula: C₁₄H₂₂O₃
• Molecular Weight: 238.327
• Mol file: 119053-78-0.mol

Synonyms:3-[1-((tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl]prop-2-yn-1-ol

Chemical Property of 3-[1-((tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl]prop-2-yn-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[1-((tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl]prop-2-yn-1-ol

There total 8 articles about 3-[1-((tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl]prop-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(1-ethynyl-cyclohexyloxy)-tetrahydro-pyran (42969-66-4) → 3-[1-((tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl]prop-2-yn-1-ol (119053-78-0)

Guidance literature:

With tetraethylammonium tosylate; In N,N-dimethyl-formamide; electrolyzed by using platinum elctrode in cathode compartiment;

DOI:10.1246/cl.1988.1977

Reference yield: 78.0%

t-butyldimethyl[(3-(1-((tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl)prop-2-yn-1-yl)oxy]silane → 3-[1-((tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl]prop-2-yn-1-ol (119053-78-0)

Guidance literature:

With tetrabutylammonium fluoride monohydrate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201609636

Reference yield:

1-Ethynylcyclohexan-1-ol (78-27-3) → 3-[1-((tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl]prop-2-yn-1-ol (119053-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: p-toluenesulfonic acid monohydrate / CH₂Cl₂ / cooling

2.1: n-butyl lithium / toluene; tetrahydrofuran / cooling

2.2: toluene; tetrahydrofuran; hexamethylphosphoric acid triamide / cooling

With n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/ol071108n

upstream raw materials:

formaldehyd

2-(1-ethynyl-cyclohexyloxy)-tetrahydro-pyran

3,4-dihydro-2H-pyran

1-Ethynylcyclohexan-1-ol

Downstream raw materials:

3-cyclohexylideneprop-2-en-1-ol

benzyl (5-cyclohexylidene-2,2-diphenyl-4-pentenyl)-carbamate

5-cyclohexylidene-2,2-diphenyl-4-pentenenitrile

benzyl 3-cyclohexylideneprop-2-en-1-yl carbonate