5'-O-dimethoxytrityl-2'-O-terbutyldimethylsilyl-3'-O-succinyl-pyridinium 2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine

Base Information

• Chemical Name: 5'-O-dimethoxytrityl-2'-O-terbutyldimethylsilyl-3'-O-succinyl-pyridinium 2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine
• CAS No.: 1542260-57-0
• Molecular Formula: C₅H₅N*C₄₇H₅₃N₃O₁₁Si
• Molecular Weight: 948.099

Synonyms:5'-O-dimethoxytrityl-2'-O-terbutyldimethylsilyl-3'-O-succinyl-pyridinium 2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine

Chemical Property of 5'-O-dimethoxytrityl-2'-O-terbutyldimethylsilyl-3'-O-succinyl-pyridinium 2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine

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Technology Process of 5'-O-dimethoxytrityl-2'-O-terbutyldimethylsilyl-3'-O-succinyl-pyridinium 2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine

There total 10 articles about 5'-O-dimethoxytrityl-2'-O-terbutyldimethylsilyl-3'-O-succinyl-pyridinium 2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoyl-cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

succinic acid anhydride (108-30-5) + 5′-O-dimethoxytrityl-2′-O-terbutyldimethylsilyl-3′-O-succinyl pyridinium salt-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N4-benzoylcytidine (1542260-47-8) → 5'-O-dimethoxytrityl-2'-O-terbutyldimethylsilyl-3'-O-succinyl-pyridinium 2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N4-benzoyl-cytidine (1542260-57-0)

Guidance literature:

With pyridine; dmap; at 37 ℃; for 14h;

Reference yield:

pyridine (110-86-1) + succinic acid anhydride (108-30-5) + 5′-O-dimethoxytrityl-2′-O-terbutyldimethylsilyl-3′-O-succinyl pyridinium salt-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N4-benzoylcytidine (1542260-47-8) → 5'-O-dimethoxytrityl-2'-O-terbutyldimethylsilyl-3'-O-succinyl-pyridinium 2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N4-benzoyl-cytidine (1542260-57-0)

Guidance literature:

With dmap; at 37 ℃; for 14h; Sealed tube;

Reference yield:

1-O-acetate-α/β-2,3,5-tribenzoyl-2,3,4,5,5′-pentadeuterium-D-ribofuranoside → 5'-O-dimethoxytrityl-2'-O-terbutyldimethylsilyl-3'-O-succinyl-pyridinium 2',3',5'-trihydroxy-2',3',4',5',5-pentadeuterium-β-D-ribofuranosyl-N4-benzoyl-cytidine (1542260-57-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane; ammonium sulfate / 15 h / Reflux

1.2: 0.25 h / 40 °C

1.3: 2.5 h / Reflux

2.1: sodium hydroxide; water; pyridine / methanol / 0.33 h / 0 °C

3.1: pyridine / 5 h / 0 °C

4.1: silver nitrate; pyridine / tetrahydrofuran / 0.17 h / 20 °C

4.2: 2.5 h / 20 °C / Sealed tube

5.1: dmap / 14 h / 37 °C / Sealed tube

With pyridine; dmap; ammonium sulfate; water; silver nitrate; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; In tetrahydrofuran; methanol;

upstream raw materials:

succinic acid anhydride

5′-O-dimethoxytrityl-2′-O-terbutyldimethylsilyl-3′-O-succinyl pyridinium salt-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoylcytidine

pyridine

2′,3′,5′-tri-O-benzoyl-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N⁴-benzoylcytidine

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