[5-chloro-2-(4-nitrophenylethynyl)phenyl]phosphonic acid monoethyl ester

Base Information

Chemical Name:[5-chloro-2-(4-nitrophenylethynyl)phenyl]phosphonic acid monoethyl ester
CAS No.:639517-09-2
Molecular Formula:C₁₆H₁₃ClNO₅P
Molecular Weight:365.71
Hs Code.:

Synonyms:[5-chloro-2-(4-nitrophenylethynyl)phenyl]phosphonic acid monoethyl ester

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Chemical Property of [5-chloro-2-(4-nitrophenylethynyl)phenyl]phosphonic acid monoethyl ester

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Technology Process of [5-chloro-2-(4-nitrophenylethynyl)phenyl]phosphonic acid monoethyl ester

There total 3 articles about [5-chloro-2-(4-nitrophenylethynyl)phenyl]phosphonic acid monoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 639516-97-5
[5-chloro-2-(4-nitro-phenylethynyl)-phenyl]phosphonic acid diethyl ester

: 639517-09-2
[5-chloro-2-(4-nitrophenylethynyl)phenyl]phosphonic acid monoethyl ester

Guidance literature:: With sodium hydroxide; In ethanol; Heating;
DOI:10.1021/ja038627f

Reference yield:

: 83110-00-3
diethyl 5-chloro-2-hydroxyphenyl phosphonate

: 639517-09-2
[5-chloro-2-(4-nitrophenylethynyl)phenyl]phosphonic acid monoethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / Et₃N / 8 h / 20 °C

2: 60 percent / PdCl₂(PPh₃)2; Et₃N / dimethylformamide / 5 h / 80 °C

3: 96 percent / aq. NaOH / ethanol / Heating

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja038627f

Reference yield:

: 639516-89-5
4-chloro-2-(diethoxyphosphonyl)phenyl 1,1,2,2-tetra-fluoro-2-(1,1,2,2-tetrafluoroethoxy)ethanesulfonate

: 639517-09-2
[5-chloro-2-(4-nitrophenylethynyl)phenyl]phosphonic acid monoethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / PdCl₂(PPh₃)2; Et₃N / dimethylformamide / 5 h / 80 °C

2: 96 percent / aq. NaOH / ethanol / Heating

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja038627f