2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide

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Chemical Name:2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide
CAS No.:207235-13-0
Molecular Formula:C₂₉H₂₄FN₅O₅
Molecular Weight:541.538
Hs Code.:

2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6<i>H</i>-pyrimidin-1-yl]-<i>N</i>-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide

Synonyms:2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide

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Chemical Property of 2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide

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Technology Process of 2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide

There total 8 articles about 2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 207235-12-9
[1-{[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethylcarbamoyl]-methyl}-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester

: 207235-13-0
2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide

Guidance literature:: With trifluorormethanesulfonic acid; methoxybenzene; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/jm000496v

Reference yield:

: 59830-60-3,63219-70-5,68474-26-0
N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde

: 207235-13-0
2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

2: HCl / CHCl₃ / 3 h / 0 °C

3: ethanol / 6 h / Heating

4: H₂ / 10percent Pd/C / methanol / 18 h / 20 °C

5: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 4 h / 20 °C

6: 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; dichloroacetic acid; DMSO / toluene / 3.5 h / 20 °C

7: trifluoromethanesulfonic acid; anisole / CH₂Cl₂ / 1 h / 0 - 20 °C

With hydrogenchloride; dichloro-acetic acid; trifluorormethanesulfonic acid; hydrogen; dimethyl sulfoxide; methoxybenzene; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 10percent Pd/C; In methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 6: modified Pfitzner-Moffatt oxidation;
DOI:10.1021/jm000496v

Reference yield:

: 20734-76-3
2-amino-4-methoxyphenol

: 207235-13-0
2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 6 h / Heating

2: H₂ / 10percent Pd/C / methanol / 18 h / 20 °C

3: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 4 h / 20 °C

4: 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; dichloroacetic acid; DMSO / toluene / 3.5 h / 20 °C

5: trifluoromethanesulfonic acid; anisole / CH₂Cl₂ / 1 h / 0 - 20 °C

With dichloro-acetic acid; trifluorormethanesulfonic acid; hydrogen; dimethyl sulfoxide; methoxybenzene; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 10percent Pd/C; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 4: modified Pfitzner-Moffatt oxidation;
DOI:10.1021/jm000496v