3-(2-Phenyl-3H-imidazol-4-yl)-2,2-bis-(2-phenyl-3H-imidazol-4-ylmethyl)-propionitrile; hydrochloride

Base Information

Chemical Name:3-(2-Phenyl-3H-imidazol-4-yl)-2,2-bis-(2-phenyl-3H-imidazol-4-ylmethyl)-propionitrile; hydrochloride
CAS No.:119336-47-9
Molecular Formula:C₃₂H₂₇N₇*3ClH
Molecular Weight:618.996
Hs Code.:

Synonyms:3-(2-Phenyl-3H-imidazol-4-yl)-2,2-bis-(2-phenyl-3H-imidazol-4-ylmethyl)-propionitrile; hydrochloride

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Chemical Property of 3-(2-Phenyl-3H-imidazol-4-yl)-2,2-bis-(2-phenyl-3H-imidazol-4-ylmethyl)-propionitrile; hydrochloride

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Technology Process of 3-(2-Phenyl-3H-imidazol-4-yl)-2,2-bis-(2-phenyl-3H-imidazol-4-ylmethyl)-propionitrile; hydrochloride

There total 6 articles about 3-(2-Phenyl-3H-imidazol-4-yl)-2,2-bis-(2-phenyl-3H-imidazol-4-ylmethyl)-propionitrile; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 119336-45-7
tris<<1-(methoxymethyl)-2-phenyl-5-imidazolyl>methyl>acetonitrile

: 119336-47-9
3-(2-Phenyl-3H-imidazol-4-yl)-2,2-bis-(2-phenyl-3H-imidazol-4-ylmethyl)-propionitrile; hydrochloride

Guidance literature:: With hydrogenchloride; In acetic acid; for 7h; Heating;
DOI:10.1021/jo00267a038

Reference yield:

: 670-96-2
2-Phenylimidazole

: 119336-47-9
3-(2-Phenyl-3H-imidazol-4-yl)-2,2-bis-(2-phenyl-3H-imidazol-4-ylmethyl)-propionitrile; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 30 min, 2.) RT, overnight

2: 1.) sec-BuLi / 1.) THF, hexane, from -40 to -35 deg C, 30 min, 2.) RT, overnight

3: NaBH₄ / methanol / Ambient temperature

4: 100 percent / SOCl₂ / CHCl₃ / 1.) RT, overnight, 2.) from 40 to 45 deg C, 30 min

5: 18 percent / LDA / tetrahydrofuran / 20 h / Ambient temperature

6: 53 percent / aq. HCl / acetic acid / 7 h / Heating

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; thionyl chloride; sec.-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; methanol; chloroform; acetic acid;
DOI:10.1021/jo00267a038

Reference yield:

: 112655-31-9
1-methoxymethyl-2-phenyl-1H-imidazole

: 119336-47-9
3-(2-Phenyl-3H-imidazol-4-yl)-2,2-bis-(2-phenyl-3H-imidazol-4-ylmethyl)-propionitrile; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) sec-BuLi / 1.) THF, hexane, from -40 to -35 deg C, 30 min, 2.) RT, overnight

2: NaBH₄ / methanol / Ambient temperature

3: 100 percent / SOCl₂ / CHCl₃ / 1.) RT, overnight, 2.) from 40 to 45 deg C, 30 min

4: 18 percent / LDA / tetrahydrofuran / 20 h / Ambient temperature

5: 53 percent / aq. HCl / acetic acid / 7 h / Heating

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; sec.-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; methanol; chloroform; acetic acid;
DOI:10.1021/jo00267a038