Technology Process of (+/-)-WMS-1410
There total 10 articles about (+/-)-WMS-1410 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 0.5h;
under 750.075 Torr;
DOI:10.1016/j.bmc.2010.09.026
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere
2.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux
2.2: 1 h / Cooling with ice
3.1: potassium carbonate / acetone / 4 h / Reflux
4.1: sodium tetrahydroborate; methanol / 1 h / 20 °C
5.1: methanol; magnesium / 5 h / Reflux
6.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / Reflux
7.1: palladium 10% on activated carbon; hydrogen / methanol / 0.5 h / 20 °C
With
methanol; aluminum (III) chloride; sodium tetrahydroborate; phosphorus pentoxide; palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium;
In
methanol; dichloromethane; 1,2-dichloro-ethane; acetone; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: pyridine / 1.5 h / 20 °C
2.1: potassium carbonate / acetone / 20 h / Reflux
3.1: sodium hydroxide; water / ethanol / 5 h / Reflux
4.1: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere
5.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux
5.2: 1 h / Cooling with ice
6.1: potassium carbonate / acetone / 4 h / Reflux
7.1: sodium tetrahydroborate; methanol / 1 h / 20 °C
8.1: methanol; magnesium / 5 h / Reflux
9.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / Reflux
10.1: palladium 10% on activated carbon; hydrogen / methanol / 0.5 h / 20 °C
With
pyridine; methanol; aluminum (III) chloride; sodium tetrahydroborate; phosphorus pentoxide; palladium 10% on activated carbon; water; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; sodium hydroxide;
In
methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; acetone; acetonitrile;
