(+/-)-WMS-1418

Base Information

• Chemical Name: (+/-)-WMS-1418
• CAS No.: 1253197-30-6
• Molecular Formula: C₂₇H₃₁NO₂
• Molecular Weight: 401.549
• Mol file: 1253197-30-6.mol

Synonyms:(+/-)-WMS-1418

Chemical Property of (+/-)-WMS-1418

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-WMS-1418

There total 11 articles about (+/-)-WMS-1418 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-Chloro-4-phenylbutane (4830-93-7) + (+/-)-7-benzyloxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol (1253197-26-0) → (+/-)-WMS-1418 (1253197-30-6)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetonitrile; for 72h; Reflux;

DOI:10.1002/cmdc.201700819

Reference yield:

(+/-)-7-benzyloxy-3-(4-tosyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol (1253197-29-3) → (+/-)-WMS-1418 (1253197-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; magnesium / 5 h / Reflux

2: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / Reflux

With methanol; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; In acetonitrile;

Reference yield:

7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one (81593-57-9) → (+/-)-WMS-1418 (1253197-30-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux

1.2: 1 h / Cooling with ice

2.1: potassium carbonate / acetone / 4 h / Reflux

3.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

4.1: methanol; magnesium / 5 h / Reflux

5.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / Reflux

With methanol; aluminum (III) chloride; sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; In dichloromethane; acetone; acetonitrile;

upstream raw materials:

1-Chloro-4-phenylbutane

(+/-)-7-benzyloxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one

N-[(3-methoxyphenyl)ethyl]-4′′-methylbenzenesulfonamide

Downstream raw materials:

(+/-)-WMS-1410