1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(2-(1-methyl-1H-pyrazol-4-yl)-4-phenylthiazol-5-yl )urea

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Chemical Name:1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(2-(1-methyl-1H-pyrazol-4-yl)-4-phenylthiazol-5-yl )urea
CAS No.:1610354-48-7
Molecular Formula:C₂₇H₂₈F₂N₆O₂S
Molecular Weight:538.621
Hs Code.:

Synonyms:1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(2-(1-methyl-1H-pyrazol-4-yl)-4-phenylthiazol-5-yl )urea

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Chemical Property of 1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(2-(1-methyl-1H-pyrazol-4-yl)-4-phenylthiazol-5-yl )urea

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Technology Process of 1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(2-(1-methyl-1H-pyrazol-4-yl)-4-phenylthiazol-5-yl )urea

There total 7 articles about 1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(2-(1-methyl-1H-pyrazol-4-yl)-4-phenylthiazol-5-yl )urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: (3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-amine dihydrochloride

: 1610354-69-2
2-(2-methylpyrimidin-5-yl)-4-phenylthiazol-5-amine

: 1610354-48-7
1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(2-(1-methyl-1H-pyrazol-4-yl)-4-phenylthiazol-5-yl )urea

Guidance literature:: bis(trichloromethyl) carbonate; 2-(2-methylpyrimidin-5-yl)-4-phenylthiazol-5-amine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

(3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-amine dihydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 16h;

Reference yield:

: 906099-50-1
2-bromo-4-phenylthiazole-5-carboxylic acid

: 1610354-48-7
1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(2-(1-methyl-1H-pyrazol-4-yl)-4-phenylthiazol-5-yl )urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 16 h / 95 °C

2.1: triethylamine; diphenyl phosphoryl azide / 16 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

4.2: 16 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; toluene;

Reference yield:

: 64399-23-1
ethyl 4-phenyl-2-aminothiazole-5-carboxylate

: 1610354-48-7
1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(2-(1-methyl-1H-pyrazol-4-yl)-4-phenylthiazol-5-yl )urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(I) bromide; tert.-butylnitrite / acetonitrile / 16 h / 0 - 20 °C / Inert atmosphere

2.1: potassium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 16 h / 95 °C

4.1: triethylamine; diphenyl phosphoryl azide / 16 h / Reflux

5.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

6.2: 16 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; diphenyl phosphoryl azide; water; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; copper(I) bromide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; acetonitrile;