906099-50-1

Basic information

• Product Name: 2-BroMo-4-phenylthiazole-5-carboxylic acid
• Synonyms: 2-BroMo-4-phenylthiazole-5-carboxylic acid;2-Bromo-4-phenyl-1,3-thiazole-5-carboxylic acid
• CAS NO: 906099-50-1
• Molecular Formula: C₁₀H₆BrNO₂S
• Molecular Weight: 284.12914
• Mol File: 906099-50-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BroMo-4-phenylthiazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-4-phenylthiazole-5-carboxylic acid(906099-50-1)
• EPA Substance Registry System: 2-BroMo-4-phenylthiazole-5-carboxylic acid(906099-50-1)

Safety Data

• Hazardous Substances Data: 906099-50-1(Hazardous Substances Data)

Upstream product

• 64399-23-1 ethyl 4-phenyl-2-aminothiazole-5-carboxylate 
• 55919-47-6 ethyl 2-bromo-3-oxo-3-phenylpropionate 
• 177328-30-2 ethyl-2-bromo-4-phenyl-1,3-thiazol-5-carboxylate 

Downstream Products

• 1610354-68-1 tert-butyl (2-(2-methylpyrimidin-5-yl)-4-phenylthiazol-5-yl)carbamate 
• 1610354-69-2 2-(2-methylpyrimidin-5-yl)-4-phenylthiazol-5-amine 
• 1610354-48-7 1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(2-(1-methyl-1H-pyrazol-4-yl)-4-phenylthiazol-5-yl )urea 
• 1610354-67-0 2-(2-methylpyrimidin-5-yl)-4-phenylthiazole-5-carboxylic acid 

Relevant articles and documents

PYRROLIDINYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS

Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH-C(=X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.