906099-50-1

Upstream product

• 177328-30-2 ethyl-2-bromo-4-phenyl-1,3-thiazol-5-carboxylate 
• 55919-47-6 ethyl 2-bromo-3-oxo-3-phenylpropionate 
• 64399-23-1 ethyl 4-phenyl-2-aminothiazole-5-carboxylate 

Downstream Products

• 1610354-68-1 tert-butyl (2-(2-methylpyrimidin-5-yl)-4-phenylthiazol-5-yl)carbamate 
• 1610354-69-2 2-(2-methylpyrimidin-5-yl)-4-phenylthiazol-5-amine 
• 1610354-48-7 1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(2-(1-methyl-1H-pyrazol-4-yl)-4-phenylthiazol-5-yl )urea 
• 1610354-67-0 2-(2-methylpyrimidin-5-yl)-4-phenylthiazole-5-carboxylic acid 

Relevant academic research and scientific papers

PYRROLIDINYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS

Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH-C(=X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY

The invention provides compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein A, R1, R2 and R3 are as defined in the specification; a process for their preparation; pharmaceutical compositions con