diethyl 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzyl phosphonate

Base Information

Chemical Name:diethyl 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzyl phosphonate
CAS No.:852948-01-7
Molecular Formula:C₂₄H₂₄Cl₂FO₅P
Molecular Weight:513.33
Hs Code.:

Synonyms:diethyl 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzyl phosphonate

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Chemical Property of diethyl 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzyl phosphonate

Chemical Property:

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Technology Process of diethyl 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzyl phosphonate

There total 5 articles about diethyl 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzyl phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 852948-00-6
3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzyl bromide

: 122-52-1
triethyl phosphite

: 852948-01-7
diethyl 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzyl phosphonate

Guidance literature:: In toluene; at 20 - 120 ℃; for 8h;

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 852948-01-7
diethyl 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzyl phosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium tetrachloride / dichloromethane / 192 h / 20 °C

2.1: triethylsilane / dichloromethane; trifluoroacetic acid / 16 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 h / 0 - 20 °C

3.2: 0 °C

4.1: boron tribromide / dichloromethane / 16 h / -78 - 20 °C

5.1: toluene / 8 h / 20 - 120 °C

With triethylsilane; lithium aluminium tetrahydride; boron tribromide; titanium tetrachloride; In tetrahydrofuran; dichloromethane; toluene; trifluoroacetic acid;

Reference yield:

: 852947-86-5
methyl 3,5-dichloro-4-(4'-hydroxyphenoxy)benzoate

: 852948-01-7
diethyl 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzyl phosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium tetrachloride / dichloromethane / 192 h / 20 °C

2.1: triethylsilane / dichloromethane; trifluoroacetic acid / 16 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 h / 0 - 20 °C

3.2: 0 °C

4.1: boron tribromide / dichloromethane / 16 h / -78 - 20 °C

5.1: toluene / 8 h / 20 - 120 °C

With triethylsilane; lithium aluminium tetrahydride; boron tribromide; titanium tetrachloride; In tetrahydrofuran; dichloromethane; toluene; trifluoroacetic acid;