3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzylphosphonic acid

Base Information

Chemical Name:3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzylphosphonic acid
CAS No.:852947-96-7
Molecular Formula:C₂₀H₁₆Cl₂FO₅P
Molecular Weight:457.222
Hs Code.:

Synonyms:3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzylphosphonic acid

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Chemical Property of 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzylphosphonic acid

Chemical Property:

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Technology Process of 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzylphosphonic acid

There total 5 articles about 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 852948-01-7
diethyl 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzyl phosphonate

: 852947-96-7
3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzylphosphonic acid

Guidance literature:: diethyl 3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzyl phosphonate; With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃; for 16.5h;

With water;

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 852947-96-7
3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzylphosphonic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium tetrachloride / dichloromethane / 192 h / 20 °C

2.1: triethylsilane / dichloromethane; trifluoroacetic acid / 16 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 h / 0 - 20 °C

3.2: 0 °C

4.1: boron tribromide / dichloromethane / 16 h / -78 - 20 °C

5.1: toluene / 8 h / 20 - 120 °C

6.1: trimethylsilyl bromide / dichloromethane / 16.05 h / 0 - 20 °C

With triethylsilane; lithium aluminium tetrahydride; trimethylsilyl bromide; boron tribromide; titanium tetrachloride; In tetrahydrofuran; dichloromethane; toluene; trifluoroacetic acid;

Reference yield:

: 852947-86-5
methyl 3,5-dichloro-4-(4'-hydroxyphenoxy)benzoate

: 852947-96-7
3,5-dichloro-4-[3'-(4-fluorobenzyl)-4'-hydroxyphenoxy]benzylphosphonic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium tetrachloride / dichloromethane / 192 h / 20 °C

2.1: triethylsilane / dichloromethane; trifluoroacetic acid / 16 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 h / 0 - 20 °C

3.2: 0 °C

4.1: boron tribromide / dichloromethane / 16 h / -78 - 20 °C

5.1: toluene / 8 h / 20 - 120 °C

6.1: trimethylsilyl bromide / dichloromethane / 16.05 h / 0 - 20 °C

With triethylsilane; lithium aluminium tetrahydride; trimethylsilyl bromide; boron tribromide; titanium tetrachloride; In tetrahydrofuran; dichloromethane; toluene; trifluoroacetic acid;