(2S,5S)-5-(methoxycarbonyl)-1-((S)-1-phenylethyl)pyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: (2S,5S)-5-(methoxycarbonyl)-1-((S)-1-phenylethyl)pyrrolidine-2-carboxylic acid
• CAS No.: 1094542-71-8
• Molecular Formula: C₁₅H₁₉NO₄
• Molecular Weight: 277.32
• Mol file: 1094542-71-8.mol

Synonyms:(2S,5S)-5-(methoxycarbonyl)-1-((S)-1-phenylethyl)pyrrolidine-2-carboxylic acid

Chemical Property of (2S,5S)-5-(methoxycarbonyl)-1-((S)-1-phenylethyl)pyrrolidine-2-carboxylic acid

Chemical Property:

Purity/Quality:

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Technology Process of (2S,5S)-5-(methoxycarbonyl)-1-((S)-1-phenylethyl)pyrrolidine-2-carboxylic acid

There total 1 articles about (2S,5S)-5-(methoxycarbonyl)-1-((S)-1-phenylethyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-<(S)-1-Phenylethyl>-2,5-(S,S)-bis(methoxycarbonyl)pyrrolidine (134860-26-7) → (2S,5S)-5-(methoxycarbonyl)-1-((S)-1-phenylethyl)pyrrolidine-2-carboxylic acid (1094542-71-8)

Guidance literature:

With sodium hydroxide; In methanol; water; at 45 ℃; for 4.5h;

DOI:10.1055/s-0037-1610304

Reference yield: 85.0%

(2S,5S)-5-(methoxycarbonyl)-1-((S)-1-phenylethyl)pyrrolidine-2-carboxylic acid (1094542-71-8) + dimethyl amine (124-40-3) → methyl (2S,5S)-5-(dimethylcarbamoyl)-1-((S)-1-phenylethyl)pyrrolidine-2-carboxylate

Guidance literature:

(2S,5S)-5-(methoxycarbonyl)-1-((S)-1-phenylethyl)pyrrolidine-2-carboxylic acid; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In chloroform; Inert atmosphere;

dimethyl amine; In tetrahydrofuran; chloroform; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1055/s-0037-1610304

Reference yield: 34.0%

(2S,5S)-5-(methoxycarbonyl)-1-((S)-1-phenylethyl)pyrrolidine-2-carboxylic acid (1094542-71-8) → (2S,5S)-5-(methoxycarbonyl)pyrrolidine-2-carboxylic acid (111138-65-9)

Guidance literature:

With 26% Pd(OH)2/C; hydrogen; In methanol; at 20 ℃; for 15h;

DOI:10.1080/00397910802323098

upstream raw materials:

1-<(S)-1-Phenylethyl>-2,5-(S,S)-bis(methoxycarbonyl)pyrrolidine

Downstream raw materials:

(2S,5S)-5-(methoxycarbonyl)pyrrolidine-2-carboxylic acid