Technology Process of N-(cyanomethyl)-2-methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide
There total 4 articles about N-(cyanomethyl)-2-methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(2-(4-morpholinophenylamino)-5-methylpyrimidin-4-yl)-2-methoxybenzoic acid sodium salt;
With
water; citric acid;
In
ethyl acetate;
2-aminoacetonitrile hydrochloride;
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
dmap;
In
dichloromethane; N,N-dimethyl-formamide;
for 64h;
With
HATU;
In
dichloromethane; N,N-dimethyl-formamide;
for 24h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene / 75 - 100 °C
2.1: toluene-4-sulfonic acid / 1,4-dioxane / Heating / reflux
3.1: methanol; sodium hydroxide; water / tetrahydrofuran / Heating / reflux
4.1: water; citric acid / ethyl acetate
4.2: 64 h
4.3: 24 h
With
methanol; sodium hydroxide; water; sodium carbonate; toluene-4-sulfonic acid; citric acid;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; ethyl acetate; toluene;
1.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / 1,4-dioxane / Heating / reflux
2.1: methanol; sodium hydroxide; water / tetrahydrofuran / Heating / reflux
3.1: water; citric acid / ethyl acetate
3.2: 64 h
3.3: 24 h
With
methanol; sodium hydroxide; water; toluene-4-sulfonic acid; citric acid;
In
tetrahydrofuran; 1,4-dioxane; ethyl acetate;
