N-(cyanomethyl)-2-methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide

Base Information

Chemical Name:N-(cyanomethyl)-2-methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide
CAS No.:1056635-49-4
Molecular Formula:C₂₅H₂₆N₆O₃
Molecular Weight:458.52
Hs Code.:

Synonyms:N-(cyanomethyl)-2-methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide

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Chemical Property of N-(cyanomethyl)-2-methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide

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Technology Process of N-(cyanomethyl)-2-methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide

There total 4 articles about N-(cyanomethyl)-2-methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1056635-40-5
4-(2-(4-morpholinophenylamino)-5-methylpyrimidin-4-yl)-2-methoxybenzoic acid sodium salt

: 6011-14-9
2-aminoacetonitrile hydrochloride

: 1056635-49-4
N-(cyanomethyl)-2-methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide

Guidance literature:: 4-(2-(4-morpholinophenylamino)-5-methylpyrimidin-4-yl)-2-methoxybenzoic acid sodium salt; With water; citric acid; In ethyl acetate;

2-aminoacetonitrile hydrochloride; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dmap; In dichloromethane; N,N-dimethyl-formamide; for 64h;

With HATU; In dichloromethane; N,N-dimethyl-formamide; for 24h;

Reference yield:

: 4334-88-7
p-ethoxycarbonylphenylboronic acid

: 1056635-49-4
N-(cyanomethyl)-2-methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 75 - 100 °C

2.1: toluene-4-sulfonic acid / 1,4-dioxane / Heating / reflux

3.1: methanol; sodium hydroxide; water / tetrahydrofuran / Heating / reflux

4.1: water; citric acid / ethyl acetate

4.2: 64 h

4.3: 24 h

With methanol; sodium hydroxide; water; sodium carbonate; toluene-4-sulfonic acid; citric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 499195-60-7
4-(4-carboethoxyphenyl)-2-chloropyrimidine

: 1056635-49-4
N-(cyanomethyl)-2-methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / 1,4-dioxane / Heating / reflux

2.1: methanol; sodium hydroxide; water / tetrahydrofuran / Heating / reflux

3.1: water; citric acid / ethyl acetate

3.2: 64 h

3.3: 24 h

With methanol; sodium hydroxide; water; toluene-4-sulfonic acid; citric acid; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;