ethyl 4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoate

Base Information

Chemical Name:ethyl 4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoate
CAS No.:1056634-62-8
Molecular Formula:C23H24N4O3
Molecular Weight:404.469
Hs Code.:
Mol file:1056634-62-8.mol

Synonyms:Benzoic acid,4-(1-carboxycyclopropyl)-2,3,5-trifluoro-,1-ethyl ester; ethyl 4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzoate

Suppliers and Price of ethyl 4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl4-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzoate
100mg
$ 330.00

ChemScene
ethyl4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzoate 98.74%
1g
$ 858.00

Total 11 raw suppliers

Chemical Property of ethyl 4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoate

Chemical Property:

Boiling Point:635.2±65.0 °C(Predicted)
PKA:5.24±0.40(Predicted)
PSA：76.58000
Density:1.244±0.06 g/cm3(Predicted)
LogP:4.03850

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Ethyl 4-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzoate is used as a reactant in the synthesis of CYT387, a therapeutic agent used in multiple myeloma treatment.

Technology Process of ethyl 4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoate

There total 2 articles about ethyl 4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 2524-67-6,86759-37-7
4-morpholino-4-yl-phenylamine

: 499195-60-7
4-(4-carboethoxyphenyl)-2-chloropyrimidine

: 1056634-62-8
ethyl 4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzoate

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; Heating / reflux;

Reference yield:

: 4334-88-7
p-ethoxycarbonylphenylboronic acid

: 1056634-62-8
ethyl 4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 75 - 100 °C

2: toluene-4-sulfonic acid / 1,4-dioxane / Heating / reflux

With sodium carbonate; toluene-4-sulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; toluene; 1: Suzuki Coupling;

Reference yield: 100.0%

: 1056634-62-8
ethyl 4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzoate

: 945749-71-3
4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzoic acid

Guidance literature:: ethyl 4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzoate; With methanol; lithium hydroxide; water; In tetrahydrofuran; for 2h; Heating / reflux;

With hydrogenchloride; water; In tetrahydrofuran; methanol;