2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid benzyl ester
CAS No.:199861-70-6
Molecular Formula:C₃₂H₃₄ClN₃O₄
Molecular Weight:560.093
Hs Code.:

Synonyms:2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid benzyl ester

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Chemical Property of 2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid benzyl ester

Chemical Property:

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Technology Process of 2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid benzyl ester

There total 8 articles about 2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tin(II)cloride dihydrate

: 2-{2-[6-nitro-7-chloro-3-(3.5-dimethylphenyl)-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid benzyl ester

: 144-55-8
sodium hydrogencarbonate

: 199861-70-6
2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol;

Reference yield:

: 2-acetylamino-4-chloro-5-nitrobenzoic acid methyl ester

: 199861-70-6
2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / methanol; ethyl acetate

2: methanol; 1,2-dichloro-ethane

3: hydrogenchloride; sodium hexamethyldisilazane / tetrahydrofuran

4: diisopropyl (E)-azodicarboxylate; triphenylphosphine / dichloromethane; N,N-dimethyl-formamide

5: (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol

With hydrogenchloride; sulfuric acid; sodium hexamethyldisilazane; diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 199861-67-1
4-chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-5-nitro-benzoic acid methyl ester

: 199861-70-6
2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; sodium hexamethyldisilazane / tetrahydrofuran

2: diisopropyl (E)-azodicarboxylate; triphenylphosphine / dichloromethane; N,N-dimethyl-formamide

3: (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol

With hydrogenchloride; sodium hexamethyldisilazane; diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; dichloromethane; N,N-dimethyl-formamide;