(Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-fluorophenoxy)pyridin-3-yl)acrylonitrile

Base Information

Chemical Name:(Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-fluorophenoxy)pyridin-3-yl)acrylonitrile
CAS No.:1613334-45-4
Molecular Formula:C₂₂H₁₃BrFN₃O
Molecular Weight:434.267
Hs Code.:

Synonyms:(Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-fluorophenoxy)pyridin-3-yl)acrylonitrile

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Chemical Property of (Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-fluorophenoxy)pyridin-3-yl)acrylonitrile

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Technology Process of (Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-fluorophenoxy)pyridin-3-yl)acrylonitrile

There total 3 articles about (Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-fluorophenoxy)pyridin-3-yl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1613335-19-5
4-fluorophenoxy-3-formylpyridine

: 1419874-03-5
tert-butyl 5-bromo-3-(cyanomethyl)-1H-indole-1-carboxylate

: 1613334-45-4
(Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-fluorophenoxy)pyridin-3-yl)acrylonitrile

Guidance literature:: tert-butyl 5-bromo-3-(cyanomethyl)-1H-indole-1-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h; Inert atmosphere; Darkness;

4-fluorophenoxy-3-formylpyridine; In tetrahydrofuran; mineral oil; at 20 ℃; for 1.5h;

Reference yield:

: 774-14-1
(5-bromo-1H-indol-3-yl)-acetonitrile

: 1613334-45-4
(Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-fluorophenoxy)pyridin-3-yl)acrylonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / acetonitrile / 1 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Darkness

2.2: 1.5 h / 20 °C

With dmap; sodium hydride; In tetrahydrofuran; acetonitrile; mineral oil; 2.2: |Knoevenagel Condensation;

Reference yield:

: 371-41-5
4-Fluorophenol

: 114077-82-6
4-chloronicotinaldehyde

: 1613334-45-4
(Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-fluorophenoxy)pyridin-3-yl)acrylonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

1.2: 3 h / 65 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Darkness

2.2: 1.5 h / 20 °C

With sodium hydride; In tetrahydrofuran; mineral oil; 2.2: |Knoevenagel Condensation;