774-14-1

Basic information

• Product Name: 5-Bromoindole-3-acetonitrile
• Synonyms: 5-Bromoindole-3-acetonitrile;2-(5-bromo-1H-indol-3-yl)acetonitrile
• CAS NO: 774-14-1
• Molecular Formula: C₁₀H₇BrN₂
• Molecular Weight: 235.07998
• Mol File: 774-14-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Bromoindole-3-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromoindole-3-acetonitrile(774-14-1)
• EPA Substance Registry System: 5-Bromoindole-3-acetonitrile(774-14-1)

Safety Data

• Hazardous Substances Data: 774-14-1(Hazardous Substances Data)

Usage

General Description

5-Bromoindole-3-acetonitrile is a chemical compound with the molecular formula C10H6BrN which belongs to the class of organic compounds known as bromoindoles. It is a highly reactive compound that is commonly used in the manufacturing of pharmaceuticals and agrochemicals. In addition, it has various applications in organic synthesis, as a building block for the production of other chemical compounds. 5-Bromoindole-3-acetonitrile is known for its potent biological activity and is commonly used as an intermediate in the synthesis of various biologically active molecules. Due to its versatile properties and biological significance, 5-Bromoindole-3-acetonitrile is an important compound in the chemical industry and plays a crucial role in the development of new drugs and agricultural products.

Upstream product

• 773837-37-9 sodium cyanide 
• 10075-50-0 5-bromo-1H-indole 
• 74-88-4 methyl iodide 
• 50-00-0 formaldehyd 
• 877-03-2 5-bromo-1H-indole-3-carboxaldehyde 
• 92557-51-2 5-Bromo-indole-3-carbinol 
• 830-93-3 N-[(5-bromo-1H-indol-3-yl)methyl]-N,N-dimethylamine 
• 7677-24-9 trimethylsilyl cyanide 
• 151-50-8 potassium cyanide 

Downstream Products

• 1419874-03-5 tert-butyl 5-bromo-3-(cyanomethyl)-1H-indole-1-carboxylate 
• 1613334-48-7 (Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-(trifluoromethyl)phenyl)pyridin-3-yl)acrylonitrile 
• 1613334-45-4 (Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-fluorophenoxy)pyridin-3-yl)acrylonitrile 
• 142273-20-9 kenpaullone 
• 40432-84-6 (5-bromo-1H-indol-3-yl)-acetic acid 
• 117235-22-0 methyl 2-(5-bromo-1H-indole-3-yl)acetate 
• 196081-79-5 2-(5-bromo-1H-indol-3-yl)acetamide 

Relevant articles and documents

Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst

Asymmetric dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeds under mild reaction conditions to provide fluoropyrroloindoline derivatives in a highly enantioselective manner. Various substitution patterns on the indole ring are well tolerated. To facilitate the reaction and ensure reproducibility, the addition of water is essential, and its possible role is discussed.

SELECTIVE ANTI-CANCER COMPOUNDS

A compound of formula I, wherein the compound of formula I has the structure: wherein R1 to R5, Y, L, Z and X1 to X7 have meanings given in the description, said compounds having utility in the treatment of hyperproliferative disease.

Use of derivatives of indoles for the treatment of cancer

The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.