4-{(R)-carboxy-[5-(4'-ethoxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-{(R)-carboxy-[5-(4'-ethoxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 458558-89-9
• Molecular Formula: C₂₄H₃₂N₂O₇S₂
• Molecular Weight: 524.659

Synonyms:4-{(R)-carboxy-[5-(4'-ethoxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-{(R)-carboxy-[5-(4'-ethoxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of 4-{(R)-carboxy-[5-(4'-ethoxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid tert-butyl ester

There total 2 articles about 4-{(R)-carboxy-[5-(4'-ethoxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(4'-ethoxyphenyl)-thiophene-2-sulfonyl chloride + 4-((R)-amino-carboxy-methyl)piperidine-1-carboxylic acid tert-butyl ester (177702-21-5) → 4-{(R)-carboxy-[5-(4'-ethoxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid tert-butyl ester (458558-89-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm801394m

Reference yield:

→ 4-{(R)-carboxy-[5-(4'-ethoxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid tert-butyl ester (458558-89-9)

Guidance literature:

Reference yield:

4-{(R)-carboxy-[5-(4'-ethoxyphenyl)-thiophene-2-sulfonylamino]-methyl}piperidine-1-carboxylic acid tert-butyl ester (458558-89-9) → (αR)-α-[[[5-(4-hydroxyphenyl)-2-thienyl]sulfonyl]amino]4-piperidineacetic acid (1098299-14-9)

Guidance literature:

With hydrogen bromide; In water; at 20 - 100 ℃;

upstream raw materials:

4-((R)-amino-carboxy-methyl)piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

(αR)-1-BOC-α-[[[5(4-ethoxyphenyl)-2-thienyl]sulfonyl]-amino]-piperidineacetic acid benzyl ester

(αR)-α-[[[5-(4-hydroxyphenyl)-2-thienyl]sulfonyl]amino]4-piperidineacetic acid

(R)-[5-(4'-ethoxyphenyl)-thiophene-2-sulfonylamino]-piperidin-4-yl-acetic acid hydrochloride

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