3-{(2E,4E,6E)-7-[(2R,3S,4R,5S)-5-((3E,5E)-(1R,2S)-7-Amino-2-methoxy-1,3-dimethyl-hepta-3,5-dienyl)-3,4-bis-trimethylsilanyloxy-tetrahydro-furan-2-yl]-2-methyl-hepta-2,4,6-trienoyl}-4-(4-methoxy-benzyloxy)-1-methyl-1H-pyridin-2-one

Base Information

Chemical Name:3-{(2E,4E,6E)-7-[(2R,3S,4R,5S)-5-((3E,5E)-(1R,2S)-7-Amino-2-methoxy-1,3-dimethyl-hepta-3,5-dienyl)-3,4-bis-trimethylsilanyloxy-tetrahydro-furan-2-yl]-2-methyl-hepta-2,4,6-trienoyl}-4-(4-methoxy-benzyloxy)-1-methyl-1H-pyridin-2-one
CAS No.:94958-25-5
Molecular Formula:C₄₂H₆₂N₂O₈Si₂
Molecular Weight:779.134
Hs Code.:

3-{(2E,4E,6E)-7-[(2R,3S,4R,5S)-5-((3E,5E)-(1R,2S)-7-Amino-2-methoxy-1,3-dimethyl-hepta-3,5-dienyl)-3,4-bis-trimethylsilanyloxy-tetrahydro-furan-2-yl]-2-methyl-hepta-2,4,6-trienoyl}-4-(4-methoxy-benzyloxy)-1-methyl-1H-pyridin-2-one

Synonyms:3-{(2E,4E,6E)-7-[(2R,3S,4R,5S)-5-((3E,5E)-(1R,2S)-7-Amino-2-methoxy-1,3-dimethyl-hepta-3,5-dienyl)-3,4-bis-trimethylsilanyloxy-tetrahydro-furan-2-yl]-2-methyl-hepta-2,4,6-trienoyl}-4-(4-methoxy-benzyloxy)-1-methyl-1H-pyridin-2-one

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Chemical Property of 3-{(2E,4E,6E)-7-[(2R,3S,4R,5S)-5-((3E,5E)-(1R,2S)-7-Amino-2-methoxy-1,3-dimethyl-hepta-3,5-dienyl)-3,4-bis-trimethylsilanyloxy-tetrahydro-furan-2-yl]-2-methyl-hepta-2,4,6-trienoyl}-4-(4-methoxy-benzyloxy)-1-methyl-1H-pyridin-2-one

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Technology Process of 3-{(2E,4E,6E)-7-[(2R,3S,4R,5S)-5-((3E,5E)-(1R,2S)-7-Amino-2-methoxy-1,3-dimethyl-hepta-3,5-dienyl)-3,4-bis-trimethylsilanyloxy-tetrahydro-furan-2-yl]-2-methyl-hepta-2,4,6-trienoyl}-4-(4-methoxy-benzyloxy)-1-methyl-1H-pyridin-2-one

There total 8 articles about 3-{(2E,4E,6E)-7-[(2R,3S,4R,5S)-5-((3E,5E)-(1R,2S)-7-Amino-2-methoxy-1,3-dimethyl-hepta-3,5-dienyl)-3,4-bis-trimethylsilanyloxy-tetrahydro-furan-2-yl]-2-methyl-hepta-2,4,6-trienoyl}-4-(4-methoxy-benzyloxy)-1-methyl-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94958-21-1
{(2E,4E)-(6S,7R)-7-[(3aR,4S,6R,6aS)-2,2-Dimethyl-6-((E)-3-oxo-propenyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-6-methoxy-5-methyl-octa-2,4-dienyl}-carbamic acid 2,2,2-trichloro-ethyl ester

: 94958-25-5
3-{(2E,4E,6E)-7-[(2R,3S,4R,5S)-5-((3E,5E)-(1R,2S)-7-Amino-2-methoxy-1,3-dimethyl-hepta-3,5-dienyl)-3,4-bis-trimethylsilanyloxy-tetrahydro-furan-2-yl]-2-methyl-hepta-2,4,6-trienoyl}-4-(4-methoxy-benzyloxy)-1-methyl-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: NaN(SiMe₃)2 / toluene / 0.5 h / -78 - 0 °C

2: Me₃SiI / CH₂Cl₂ / 0.03 h / 0 °C

3: amberlyst-15 / dimethylformamide; H₂O / 25 °C

4: n-Bu₄NI / tetrahydrofuran / 25 °C

5: Zn / tetrahydrofuran / 25 °C / pH 7.2

6: CH₂Cl₂ / 25 °C

With amberlyst-15; trimethylsilyl iodide; sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; zinc; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja00292a039

Reference yield:

: [(E)-4-(4-Benzyloxy-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-3-methyl-4-oxo-but-2-enyl]-triphenyl-phosphonium; bromide

: 94958-25-5
3-{(2E,4E,6E)-7-[(2R,3S,4R,5S)-5-((3E,5E)-(1R,2S)-7-Amino-2-methoxy-1,3-dimethyl-hepta-3,5-dienyl)-3,4-bis-trimethylsilanyloxy-tetrahydro-furan-2-yl]-2-methyl-hepta-2,4,6-trienoyl}-4-(4-methoxy-benzyloxy)-1-methyl-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: NaN(SiMe₃)2 / toluene / 0.5 h / -78 - 0 °C

2: Me₃SiI / CH₂Cl₂ / 0.03 h / 0 °C

3: amberlyst-15 / dimethylformamide; H₂O / 25 °C

4: n-Bu₄NI / tetrahydrofuran / 25 °C

5: Zn / tetrahydrofuran / 25 °C / pH 7.2

6: CH₂Cl₂ / 25 °C

With amberlyst-15; trimethylsilyl iodide; sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; zinc; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja00292a039

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 94958-25-5
3-{(2E,4E,6E)-7-[(2R,3S,4R,5S)-5-((3E,5E)-(1R,2S)-7-Amino-2-methoxy-1,3-dimethyl-hepta-3,5-dienyl)-3,4-bis-trimethylsilanyloxy-tetrahydro-furan-2-yl]-2-methyl-hepta-2,4,6-trienoyl}-4-(4-methoxy-benzyloxy)-1-methyl-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: n-Bu₄NI / tetrahydrofuran / 25 °C

2: Zn / tetrahydrofuran / 25 °C / pH 7.2

3: CH₂Cl₂ / 25 °C

With tetra-(n-butyl)ammonium iodide; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00292a039