3-cyano-4,5-dimethyl-2-benzoyloxyacetophenone

Base Information

• Chemical Name: 3-cyano-4,5-dimethyl-2-benzoyloxyacetophenone
• CAS No.: 129696-70-4
• Molecular Formula: C₁₈H₁₅NO₃
• Molecular Weight: 293.322
• Mol file: 129696-70-4.mol

Synonyms:3-cyano-4,5-dimethyl-2-benzoyloxyacetophenone

Chemical Property of 3-cyano-4,5-dimethyl-2-benzoyloxyacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-cyano-4,5-dimethyl-2-benzoyloxyacetophenone

There total 2 articles about 3-cyano-4,5-dimethyl-2-benzoyloxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-cyano-4,5-dimethyl-2-hydroxyacetophenone (89638-56-2) + benzoyl chloride (98-88-4) → 3-cyano-4,5-dimethyl-2-benzoyloxyacetophenone (129696-70-4)

Guidance literature:

With triethylamine; In 1,4-dioxane; 1.) a) 30 min, b) RT, overnight;

Reference yield:

6-Acetyl-1-amino-3,4-dimethyl-7-oxa-bicyclo[2.2.1]hept-2-ene-2-carbonitrile → 3-cyano-4,5-dimethyl-2-benzoyloxyacetophenone (129696-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. HCl / H₂O; acetone / 2 h / 80 °C

2: 79 percent / 1.) a) Et₃N / dioxane / 1.) a) 30 min, b) RT, overnight

With hydrogenchloride; triethylamine; In 1,4-dioxane; water; acetone;

Reference yield: 76.0%

3-cyano-4,5-dimethyl-2-benzoyloxyacetophenone (129696-70-4) → α-benzoyl-2-hydroxy-3-cyano-4,5-dimethylacetophenone (129696-81-7)

Guidance literature:

With pyridine; potassium hydroxide; 1.) a) reflux, 2 h, b) RT, overnight;

upstream raw materials:

3-cyano-4,5-dimethyl-2-hydroxyacetophenone

benzoyl chloride

Downstream raw materials:

α-benzoyl-2-hydroxy-3-cyano-4,5-dimethylacetophenone

8-cyano-6,7-dimethylflavone

8-carboxamido-6,7-dimethylflavone

6,7-dimethyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid