N₁-cyclopropyl-N₂-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)oxalamide

Base Information

• Chemical Name: N₁-cyclopropyl-N₂-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)oxalamide
• CAS No.: 1200796-95-7
• Molecular Formula: C₁₇H₂₀F₃N₃O₆S
• Molecular Weight: 451.424

Synonyms:N₁-cyclopropyl-N₂-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)oxalamide

Chemical Property of N₁-cyclopropyl-N₂-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)oxalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-cyclopropyl-N₂-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)oxalamide

There total 7 articles about N₁-cyclopropyl-N₂-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)oxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

N-[1-(4-trifluoromethoxybenzenesulfonyl)piperidin-4-yloxy]oxalamic acid (1200798-01-1) + Cyclopropylamine (765-30-0) → N1-cyclopropyl-N2-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)oxalamide (1200796-95-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

2-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)isoindoline-1,3-dione (1092408-10-0) → N1-cyclopropyl-N2-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)oxalamide (1200796-95-7)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 2 h / 50 °C

2: triethylamine / dichloromethane / 2 h / 20 °C

3: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

With water; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-ol (1092408-14-4) → N1-cyclopropyl-N2-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)oxalamide (1200796-95-7)

Guidance literature:

Multi-step reaction with 5 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

2: hydrazine hydrate / ethanol / 2 h / 50 °C

3: triethylamine / dichloromethane / 2 h / 20 °C

4: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

With water; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Mitsunobu reaction;

upstream raw materials:

N-[1-(4-trifluoromethoxybenzenesulfonyl)piperidin-4-yloxy]oxalamic acid

Cyclopropylamine

1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-one

1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1200796-95-7 N₁-cyclopropyl-N₂-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)oxalamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send