6-chloro-N-methyl-N-(4-(trifluoromethoxy)phenyl)-pyrimidin-4-amine

Base Information

• Chemical Name: 6-chloro-N-methyl-N-(4-(trifluoromethoxy)phenyl)-pyrimidin-4-amine
• CAS No.: 959573-80-9
• Molecular Formula: C₁₂H₉ClF₃N₃O
• Molecular Weight: 303.671
• Mol file: 959573-80-9.mol

Synonyms:6-chloro-N-methyl-N-(4-(trifluoromethoxy)phenyl)-pyrimidin-4-amine

Chemical Property of 6-chloro-N-methyl-N-(4-(trifluoromethoxy)phenyl)-pyrimidin-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 6-chloro-N-methyl-N-(4-(trifluoromethoxy)phenyl)-pyrimidin-4-amine

There total 1 articles about 6-chloro-N-methyl-N-(4-(trifluoromethoxy)phenyl)-pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(6-chloropyrimidin-4-yl)-(3-trifluoromethoxyphenyl)-amine (714962-04-6) + methyl iodide (74-88-4) → 6-chloro-N-methyl-N-(4-(trifluoromethoxy)phenyl)-pyrimidin-4-amine (959573-80-9)

Guidance literature:

(6-chloropyrimidin-4-yl)-(3-trifluoromethoxyphenyl)-amine; With sodium hydride; In N,N-dimethyl-formamide; for 0.333333h;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

DOI:10.1021/ja303858w

Reference yield: 59.0%

6-chloro-N-methyl-N-(4-(trifluoromethoxy)phenyl)-pyrimidin-4-amine (959573-80-9) + (3-(aminocarbonyl)phenyl)boronic acid (351422-73-6) → 3-(6-(methyl(4-(trifluoromethoxy)phenyl)amino)-pyrimidin-4-yl)benzamide (959575-91-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; at 90 ℃; for 7h; Inert atmosphere;

DOI:10.1021/ja303858w

Reference yield:

6-chloro-N-methyl-N-(4-(trifluoromethoxy)phenyl)-pyrimidin-4-amine (959573-80-9) + 4-pyridylboronic acid (1692-15-5) → N-methyl-6-(pyridin-4-yl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-4-amine (778272-44-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; at 90 ℃; for 8h; Inert atmosphere;

DOI:10.1021/jm100555f

upstream raw materials:

(6-chloropyrimidin-4-yl)-(3-trifluoromethoxyphenyl)-amine

methyl iodide

Downstream raw materials:

N-methyl-6-(pyridin-4-yl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-4-amine

3-(6-(methyl(4-(trifluoromethoxy)phenyl)amino)-pyrimidin-4-yl)benzamide