(6-Chloro-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine

Base Information

• Chemical Name: (6-Chloro-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine
• CAS No.: 714962-04-6
• Molecular Formula: C₁₁H₇ClF₃N₃O
• Molecular Weight: 289.644
• European Community (EC) Number: 824-482-4
• Mol file: 714962-04-6.mol

Synonyms:714962-04-6;(6-chloro-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine;6-chloro-N-[4-(trifluoromethoxy)phenyl]pyrimidin-4-amine;6-chloro-N-(4-(trifluoromethoxy)phenyl)pyrimidin-4-amine;starbld0037954;SCHEMBL925183;AKOS010530603;EN300-1723956;(6-chloropyrimidin-4-yl)-(4-trifluoromethoxyphenyl)-amine;(4-Chloro-pyrimidin-6-yl)-(4-trifluoromethoxy-phenyl)-amine

Chemical Property of (6-Chloro-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 289.0229740
• Heavy Atom Count: 19
• Complexity: 285

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1NC2=CC(=NC=N2)Cl)OC(F)(F)F

Technology Process of (6-Chloro-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine

There total 1 articles about (6-Chloro-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4,6-dichloropyrimidine (1193-21-1) + 4-(trifluoromethoxy)aniline (461-82-5) → (6-chloropyrimidin-4-yl)-(3-trifluoromethoxyphenyl)-amine (714962-04-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 80 ℃; for 16h;

DOI:10.1021/jm100555f

Reference yield: 95.0%

(6-chloropyrimidin-4-yl)-(3-trifluoromethoxyphenyl)-amine (714962-04-6) + (p-hydroxyphenyl)boronic acid (71597-85-8) → 4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenol

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; Inert atmosphere; Reflux;

Reference yield: 95.0%

(6-chloropyrimidin-4-yl)-(3-trifluoromethoxyphenyl)-amine (714962-04-6) + methyl iodide (74-88-4) → 6-chloro-N-methyl-N-(4-(trifluoromethoxy)phenyl)-pyrimidin-4-amine (959573-80-9)

Guidance literature:

(6-chloropyrimidin-4-yl)-(3-trifluoromethoxyphenyl)-amine; With sodium hydride; In N,N-dimethyl-formamide; for 0.333333h;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

DOI:10.1021/ja303858w

upstream raw materials:

4,6-dichloropyrimidine

4-(trifluoromethoxy)aniline

Downstream raw materials:

2-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide

6-morpholino-N-(4-(trifluoromethoxy)phenyl)pyrimidin-4-amine

6-(1H-imidazol-1-yl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-4-amine

GNF-1