12-(4-Nitro-phenylamino)-dodecanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Base Information

• Chemical Name: 12-(4-Nitro-phenylamino)-dodecanoic acid 2,5-dioxo-pyrrolidin-1-yl ester
• CAS No.: 125802-85-9
• Molecular Formula: C₂₂H₃₁N₃O₆
• Molecular Weight: 433.505
• Mol file: 125802-85-9.mol

Synonyms:12-(4-Nitro-phenylamino)-dodecanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Chemical Property of 12-(4-Nitro-phenylamino)-dodecanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 12-(4-Nitro-phenylamino)-dodecanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 3 articles about 12-(4-Nitro-phenylamino)-dodecanoic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 12-(4-Nitro-phenylamino)-dodecanoic acid 2,5-dioxo-pyrrolidin-1-yl ester (125802-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / KOH / ethanol / 24 h / Heating

2: dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, overnight

With potassium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol;

DOI:10.1021/ja00163a005

Reference yield:

12-Aminododecanoic acid (693-57-2) → 12-(4-Nitro-phenylamino)-dodecanoic acid 2,5-dioxo-pyrrolidin-1-yl ester (125802-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / KOH / ethanol / 24 h / Heating

2: dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, overnight

With potassium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol;

DOI:10.1021/ja00163a005

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-(4-nitrophenyl)-12-aminododecanoic acid (116045-41-1) → 12-(4-Nitro-phenylamino)-dodecanoic acid 2,5-dioxo-pyrrolidin-1-yl ester (125802-85-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; 1.) 0 deg C, 1 h, 2.) RT, overnight;

DOI:10.1021/ja00163a005

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

N-(4-nitrophenyl)-12-aminododecanoic acid

4-Fluoronitrobenzene

12-Aminododecanoic acid

Downstream raw materials:

12-[12-(4-Nitro-phenylamino)-dodecanoylamino]-dodecanoic acid

(S)-2-Amino-6-{12-[12-(4-nitro-phenylamino)-dodecanoylamino]-dodecanoylamino}-hexanoic acid

12-[12-(4-Nitro-phenylamino)-dodecanoylamino]-dodecanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

(S)-2-Amino-5-{12-[12-(4-nitro-phenylamino)-dodecanoylamino]-dodecanoylamino}-pentanoic acid

Refernces