1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

Base Information

Chemical Name:1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea
CAS No.:1350454-77-1
Molecular Formula:C₂₄H₂₁N₇O₂S
Molecular Weight:471.542
Hs Code.:

Synonyms:1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

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Chemical Property of 1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

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Technology Process of 1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

There total 6 articles about 1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.8%

: 1350454-74-8
1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

: 1350454-77-1
1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

Guidance literature:: 1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 1.5h; Inert atmosphere;

With water; sodium hydrogencarbonate; Saturated solution;
DOI:10.1016/j.ejmech.2011.08.024

Reference yield:

: 1261242-10-7
benzyl 2-(3-phenylureido)ethylcarbamate

: 1350454-77-1
1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

3.1: boron tribromide / dichloromethane / 1.5 h / -78 - 20 °C / Inert atmosphere

3.2: Saturated solution

With palladium 10% on activated carbon; hydrogen; boron tribromide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.08.024

Reference yield:

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 1350454-77-1
1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 16 h / Reflux

2.1: palladium diacetate; caesium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 12 h / 80 °C

3.1: Oxone / methanol; water / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

5.1: boron tribromide / dichloromethane / 1.5 h / -78 - 20 °C / Inert atmosphere

5.2: Saturated solution

With Oxone; palladium diacetate; boron tribromide; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.08.024