1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

Base Information

Chemical Name:1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea
CAS No.:1350454-74-8
Molecular Formula:C₂₅H₂₃N₇O₂S
Molecular Weight:485.569
Hs Code.:

Synonyms:1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

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Chemical Property of 1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

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Technology Process of 1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

There total 6 articles about 1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.3%

: 6-(3-methoxyphenyl)-5-(2-(methylsulfonyl)pyrimidin-4-yl)imidazo[2,1-b]thiazole

: 53673-01-1
1-(2-aminoethyl)-3-phenylurea

: 1350454-74-8
1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 80 ℃; for 8h;
DOI:10.1016/j.ejmech.2011.08.024

Reference yield:

: 815596-13-5
6-(3-Methoxyphenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole

: 1350454-74-8
1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 2 steps

1: Oxone / methanol; water / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

With Oxone; N-ethyl-N,N-diisopropylamine; In methanol; water; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.08.024

Reference yield:

: 1261242-10-7
benzyl 2-(3-phenylureido)ethylcarbamate

: 1350454-74-8
1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.08.024