2-[(allyl-benzyl-amino)-methyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-pent-4-enoic acid methyl ester

Base Information

Chemical Name:2-[(allyl-benzyl-amino)-methyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-pent-4-enoic acid methyl ester
CAS No.:881398-70-5
Molecular Formula:C₂₄H₃₉NO₃Si
Molecular Weight:417.664
Hs Code.:

Synonyms:2-[(allyl-benzyl-amino)-methyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-pent-4-enoic acid methyl ester

Suppliers and Price of 2-[(allyl-benzyl-amino)-methyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-pent-4-enoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(allyl-benzyl-amino)-methyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-pent-4-enoic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-[(allyl-benzyl-amino)-methyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-pent-4-enoic acid methyl ester

There total 5 articles about 2-[(allyl-benzyl-amino)-methyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-pent-4-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 211859-87-9
((2-(bromomethyl)allyl)oxy)(tert-butyl)dimethylsilane

: 473914-75-9
3-(allyl-benzyl-amino)-propionic acid methyl ester

: 881398-70-5
2-[(allyl-benzyl-amino)-methyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-pent-4-enoic acid methyl ester

Guidance literature:: 3-(allyl-benzyl-amino)-propionic acid methyl ester; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

((2-(bromomethyl)allyl)oxy)(tert-butyl)dimethylsilane; With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; hexane; at -78 - -40 ℃;
DOI:10.1016/j.tet.2005.11.049

Reference yield:

: 37732-74-4
3-allylamino-propionic acid methyl ester

: 881398-70-5
2-[(allyl-benzyl-amino)-methyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-pent-4-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / K₂CO₃ / acetonitrile / 3 h / Heating

2.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 70 percent / HMPT / tetrahydrofuran; hexane / -78 - -40 °C

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1016/j.tet.2005.11.049

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 881398-70-5
2-[(allyl-benzyl-amino)-methyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-pent-4-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / TEA; DMAP / CH₂Cl₂ / 0 - 20 °C

2.1: 80 percent / DIBAL-H / tetrahydrofuran; toluene / -78 - 0 °C

3.1: 84 percent / bromine; triphenylphosphine; imidazole / CH₂Cl₂ / 0.5 h / 0 °C

4.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.2: 70 percent / HMPT / tetrahydrofuran; hexane / -78 - -40 °C

With 1H-imidazole; dmap; TEA; bromine; diisobutylaluminium hydride; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1016/j.tet.2005.11.049