N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2-difluoroethyl-2-(phenylsulfonyl)ethyl}-(R)-2-methyl-2-propanesulfinamide

Base Information

Chemical Name:N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2-difluoroethyl-2-(phenylsulfonyl)ethyl}-(R)-2-methyl-2-propanesulfinamide
CAS No.:1258523-24-8
Molecular Formula:C₃₀H₃₈F₄N₂O₄S₂Si
Molecular Weight:658.854
Hs Code.:

N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2-difluoroethyl-2-(phenylsulfonyl)ethyl}-(R)-2-methyl-2-propanesulfinamide

Synonyms:N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2-difluoroethyl-2-(phenylsulfonyl)ethyl}-(R)-2-methyl-2-propanesulfinamide

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Chemical Property of N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2-difluoroethyl-2-(phenylsulfonyl)ethyl}-(R)-2-methyl-2-propanesulfinamide

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Technology Process of N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2-difluoroethyl-2-(phenylsulfonyl)ethyl}-(R)-2-methyl-2-propanesulfinamide

There total 1 articles about N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2-difluoroethyl-2-(phenylsulfonyl)ethyl}-(R)-2-methyl-2-propanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189175-68-5
N-{(3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methylidene}-(R)-2-methyl-2-propanesulfinamide

: 1535-65-5
difluoromethyl phenyl sulfone

: 1258523-24-8
N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2-difluoroethyl-2-(phenylsulfonyl)ethyl}-(R)-2-methyl-2-propanesulfinamide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

Reference yield:

: 1258523-24-8
N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2-difluoroethyl-2-(phenylsulfonyl)ethyl}-(R)-2-methyl-2-propanesulfinamide

: 1258523-25-9
N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2-difluoroethyl}-(R)-2-methyl-2-propanesulfinamide

Guidance literature:: N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2-difluoroethyl-2-(phenylsulfonyl)ethyl}-(R)-2-methyl-2-propanesulfinamide; With sodium acetate; magnesium; acetic acid; In N,N-dimethyl-formamide; at 20 ℃;

With water; In N,N-dimethyl-formamide; Cooling with ice;