{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-14-yl}-carbamic acid cyclopentyl ester

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Chemical Name:{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-14-yl}-carbamic acid cyclopentyl ester
CAS No.:1275617-56-5
Molecular Formula:C₄₄H₄₉F₃N₆O₉S
Molecular Weight:894.969
Hs Code.:

{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-14-yl}-carbamic acid cyclopentyl ester

Synonyms:{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-14-yl}-carbamic acid cyclopentyl ester

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Chemical Property of {4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-14-yl}-carbamic acid cyclopentyl ester

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Technology Process of {4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-14-yl}-carbamic acid cyclopentyl ester

There total 17 articles about {4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-14-yl}-carbamic acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1275620-42-2
{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-7-en-14-yl}-carbamic acid cyclopentyl ester

: 1275617-56-5
{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-14-yl}-carbamic acid cyclopentyl ester

Guidance literature:: With hydrogen; 5% Pd(II)/C(eggshell); In methanol; at 20 ℃; for 4h; under 3102.97 Torr;

Reference yield: 55.0%

: 1195976-54-5
C₄₄H₄₇F₃N₆O₉S

: 1275617-56-5
{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-14-yl}-carbamic acid cyclopentyl ester

Guidance literature:: With hydrogen; 5% Pd(II)/C(eggshell); In methanol; at 20 ℃; for 4h; under 3102.97 Torr; Inert atmosphere;

Reference yield:

: 54802-10-7
3-aminobenzofuran-2-carboxamide

: 1275617-56-5
{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-14-yl}-carbamic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridine / tetrahydrofuran / 12 h / 20 °C

2.1: sodium hydroxide / ethanol / 12 h / 85 °C

3.1: trichlorophosphate / 2 h / Reflux

4.1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 0 - 20 °C

4.2: 10 °C

4.3: 0.5 h / 20 °C

5.1: thionyl chloride; methanol / 1 h / Reflux

6.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 20 °C

7.1: lithium hydroxide / tetrahydrofuran / 20 °C

7.2: pH < 7

8.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 20 °C

9.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 24 h / 40 °C / Inert atmosphere

10.1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 4 h / 20 °C / 3102.97 Torr

With 4-methyl-morpholine; pyridine; methanol; thionyl chloride; potassium tert-butylate; hydrogen; benzotriazol-1-ol; HATU; sodium hydroxide; lithium hydroxide; trichlorophosphate; Hoveyda-Grubbs catalyst second generation; 5% Pd(II)/C(eggshell); In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide;