{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-7-en-14-yl}-carbamic acid cyclopentyl ester

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Chemical Name:{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-7-en-14-yl}-carbamic acid cyclopentyl ester
CAS No.:1275620-42-2
Molecular Formula:C₄₄H₄₇F₃N₆O₉S
Molecular Weight:892.953
Hs Code.:

{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-7-en-14-yl}-carbamic acid cyclopentyl ester

Synonyms:{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-7-en-14-yl}-carbamic acid cyclopentyl ester

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Chemical Property of {4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-7-en-14-yl}-carbamic acid cyclopentyl ester

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Technology Process of {4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-7-en-14-yl}-carbamic acid cyclopentyl ester

There total 14 articles about {4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-7-en-14-yl}-carbamic acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1195977-22-0
C₄₆H₅₁F₃N₆O₉S

: 1275620-42-2
{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-7-en-14-yl}-carbamic acid cyclopentyl ester

Guidance literature:: Hoveyda-Grubbs catalyst second generation; In dichloromethane; at 40 ℃; for 24h; Inert atmosphere;

Reference yield:

: 630421-49-7
(1R,2S)-1-amino-N-(cyclopropylsulfonyl)-2-vinylcyclopropanecarboxamide hydrochloride

: 1275620-42-2
{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-7-en-14-yl}-carbamic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 20 °C

2: Hoveyda-Grubbs catalyst second generation / dichloromethane / 24 h / 40 °C / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-ol; HATU; Hoveyda-Grubbs catalyst second generation; In dichloromethane;

Reference yield:

: 54802-10-7
3-aminobenzofuran-2-carboxamide

: 1275620-42-2
{4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy]-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-7-en-14-yl}-carbamic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridine / tetrahydrofuran / 12 h / 20 °C

2.1: sodium hydroxide / ethanol / 12 h / 85 °C

3.1: trichlorophosphate / 2 h / Reflux

4.1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 0 - 20 °C

4.2: 10 °C

4.3: 0.5 h / 20 °C

5.1: thionyl chloride; methanol / 1 h / Reflux

6.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 20 °C

7.1: lithium hydroxide / tetrahydrofuran / 20 °C

7.2: pH < 7

8.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 20 °C

9.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 24 h / 40 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; methanol; thionyl chloride; potassium tert-butylate; benzotriazol-1-ol; HATU; sodium hydroxide; lithium hydroxide; trichlorophosphate; Hoveyda-Grubbs catalyst second generation; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;