3-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-propionaldehyde

Base Information

Chemical Name:3-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-propionaldehyde
CAS No.:135834-02-5
Molecular Formula:C₂₂H₂₂FNO
Molecular Weight:335.421
Hs Code.:

Synonyms:3-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-propionaldehyde

Suppliers and Price of 3-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-propionaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-propionaldehyde

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-propionaldehyde

There total 5 articles about 3-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 135833-83-9
1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole

: 135834-02-5
3-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-propionaldehyde

Guidance literature:: With oxonium;
DOI:10.1021/jm00105a056

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 135834-02-5
3-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-propionaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / piperidine, HOAc / toluene / 3 h / Heating

2: 1.) Et₃N, 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride, 2.) NaOH / 1.) 70 deg C, 24 h, 2.) THF, H₂O

3: 71 percent / p-TSA / toluene; H₂O / 24 h / Heating

4: 85 percent / H₃O⁺

With piperidine; sodium hydroxide; 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride; oxonium; toluene-4-sulfonic acid; acetic acid; triethylamine; In water; toluene;
DOI:10.1021/jm00105a056

Reference yield:

: 912998-81-3
methyl 4-methyl-3-oxo-2-(phenylmethylene)pentanoate

: 135834-02-5
3-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-propionaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N, 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride, 2.) NaOH / 1.) 70 deg C, 24 h, 2.) THF, H₂O

2: 71 percent / p-TSA / toluene; H₂O / 24 h / Heating

3: 85 percent / H₃O⁺

With sodium hydroxide; 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride; oxonium; toluene-4-sulfonic acid; triethylamine; In water; toluene;
DOI:10.1021/jm00105a056