1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole

Base Information

Chemical Name:1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole
CAS No.:135833-83-9
Molecular Formula:C₂₆H₃₂FNO₂
Molecular Weight:409.544
Hs Code.:

Synonyms:1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole

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Chemical Property of 1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole

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Technology Process of 1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole

There total 4 articles about 1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 41365-75-7
aminopropane diethyl acetal

: 135833-82-8
1-(4-fluorophenyl)-5-methyl-2-phenyl-1,4-hexanedione

: 135833-83-9
1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole

Guidance literature:: With toluene-4-sulfonic acid; In water; toluene; for 24h; Heating;
DOI:10.1021/jm00105a056

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 135833-83-9
1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / piperidine, HOAc / toluene / 3 h / Heating

2: 1.) Et₃N, 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride, 2.) NaOH / 1.) 70 deg C, 24 h, 2.) THF, H₂O

3: 71 percent / p-TSA / toluene; H₂O / 24 h / Heating

With piperidine; sodium hydroxide; 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride; toluene-4-sulfonic acid; acetic acid; triethylamine; In water; toluene;
DOI:10.1021/jm00105a056

Reference yield:

: 912998-81-3
methyl 4-methyl-3-oxo-2-(phenylmethylene)pentanoate

: 135833-83-9
1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Et₃N, 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride, 2.) NaOH / 1.) 70 deg C, 24 h, 2.) THF, H₂O

2: 71 percent / p-TSA / toluene; H₂O / 24 h / Heating

With sodium hydroxide; 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride; toluene-4-sulfonic acid; triethylamine; In water; toluene;
DOI:10.1021/jm00105a056