912998-81-3

Basic information

• Product Name: methyl 4-methyl-3-oxo-2-(phenylmethylene)pentanoate
• Synonyms: methyl 4-methyl-3-oxo-2-(phenylmethylene)pentanoate
• CAS NO: 912998-81-3
• Molecular Weight: 232.279
• Mol File: 912998-81-3.mol

Chemical Properties

• CAS DataBase Reference: methyl 4-methyl-3-oxo-2-(phenylmethylene)pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-methyl-3-oxo-2-(phenylmethylene)pentanoate(912998-81-3)
• EPA Substance Registry System: methyl 4-methyl-3-oxo-2-(phenylmethylene)pentanoate(912998-81-3)

Safety Data

• Hazardous Substances Data: 912998-81-3(Hazardous Substances Data)

Upstream product

• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 
• 100-52-7 benzaldehyde 
• 563-80-4 3-methyl-butan-2-one 

Downstream Products

• 1426927-60-7 C₂₈H₃₄O₅ 
• 135834-14-9 (4R,6R)-6-{2-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-4-hydroxy-tetrahydro-pyran-2-one 
• 135833-83-9 1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole 
• 135834-02-5 3-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-propionaldehyde 
• 135833-82-8 1-(4-fluorophenyl)-5-methyl-2-phenyl-1,4-hexanedione 

Relevant articles and documents

PYRROLE COMPOUNDS AND USES THEREOF

Pyrrole compounds, compositions and methods are provided for the treatment, prevention, or amelioration of neurodegenerative diseases, cardiovascular diseases, proliferative diseases and visual disorders. In particular, pyrrole compounds, compositions and methods for the treatment of stroke are disclosed herein.

Inhibitors of Cholesterol Biosynthesis. 3. Tetrahydro-4-hydroxy-6--2H-pyran-2-one Inhibitors of HMG-CoA Reductase. 2. Effects of Introducing Substituents at Positions Three and Four of the Pyrrole Nucleus

A series of trans-tetrahydro-4-hydroxy-6--2H-pyran-2 ones and their dihydroxy acids were prepared and tested for their ability to inhibit the enzyme HMG-CoA reductase in vitro.Inhibitory potency was found to increase subtantially when substituents were introduced into positions three and four of the pyrrole ring.A systematic exploration of structure-activity relationships at these two positions led to the identification of a compound ((+)-33, (+)-(4R)-trans-2-(4-fluorophenyl)-5-(1-methylethyl)-N,3-diphenyl-1- -1H-pyrrole-4-carboxamide) with five times the inhibitory potency of the fungal metabolite compactin.