(S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-pyran-2-one

Base Information

Chemical Name:(S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-pyran-2-one
CAS No.:157758-33-3
Molecular Formula:C₁₉H₂₆O₅
Molecular Weight:334.412
Hs Code.:

Synonyms:(S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-pyran-2-one

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Chemical Property of (S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-pyran-2-one

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Technology Process of (S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-pyran-2-one

There total 14 articles about (S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132969-60-9
(2S)-3-[(4-methoxybenzyl)oxy]-2-methylpropanal

: 157758-33-3
(S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) (-)-β-methoxydiisopinocampheylborane, 3.) 3N aq. NaOH, 30percent aq. H2O2

2: 1.) n-BuLi, 3.) I₂

3: K₂CO₃ / methanol / 4 h / Ambient temperature

4: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) THF, 0 deg C, 8 h

5: 1.) DMPU, n-BuLi, 3.) TsOH, 4.) Et₃N, DBU

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydroxide; n-butyllithium; dihydrogen peroxide; iodine; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; (-)-B-methoxydiisopinocampheylborane; In methanol;

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 157758-33-3
(S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / CSA / CH₂Cl₂ / 18 h / Ambient temperature

2: 85 percent / Dibal-H / CH₂Cl₂ / 1 h / -78 °C

3: 1.) (-)-β-methoxydiisopinocampheylborane, 3.) 3N aq. NaOH, 30percent aq. H2O2

4: 1.) n-BuLi, 3.) I₂

5: K₂CO₃ / methanol / 4 h / Ambient temperature

6: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) THF, 0 deg C, 8 h

7: 1.) DMPU, n-BuLi, 3.) TsOH, 4.) Et₃N, DBU

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydroxide; n-butyllithium; camphor-10-sulfonic acid; dihydrogen peroxide; iodine; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; (-)-B-methoxydiisopinocampheylborane; In methanol; dichloromethane;

Reference yield:

: 132969-71-2
methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate

: 157758-33-3
(S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / Dibal-H / CH₂Cl₂ / 1 h / -78 °C

2: 1.) (-)-β-methoxydiisopinocampheylborane, 3.) 3N aq. NaOH, 30percent aq. H2O2

3: 1.) n-BuLi, 3.) I₂

4: K₂CO₃ / methanol / 4 h / Ambient temperature

5: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) THF, 0 deg C, 8 h

6: 1.) DMPU, n-BuLi, 3.) TsOH, 4.) Et₃N, DBU

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydroxide; n-butyllithium; dihydrogen peroxide; iodine; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; (-)-B-methoxydiisopinocampheylborane; In methanol; dichloromethane;