{(2R,6S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde

Base Information

Chemical Name:{(2R,6S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde
CAS No.:157811-04-6
Molecular Formula:C₂₁H₃₀O₅
Molecular Weight:362.466
Hs Code.:

Synonyms:{(2R,6S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde

Suppliers and Price of {(2R,6S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {(2R,6S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {(2R,6S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde

There total 10 articles about {(2R,6S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 66031-93-4
tert-butyldimethylsilyl vinyl ether

: (S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-ol

: 157811-04-6
{(2R,6S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde

Guidance literature:: With zinc(II) chloride; In dichloromethane; at -20 ℃; for 0.25h;
DOI:10.1039/c39940001147

Reference yield:

: 157758-29-7
(R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane

: 157811-04-6
{(2R,6S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1,3-dimethyl-3,4,5-tetrahydro-2(1H)-pyrimidinone, n-BuLi, 2.) H₂SO₄, 3.) TsOH, 4.) Et₃N, 1,8-diazabicyclo<5.4.0>undec-7-ene

2: 95 percent / diisobutylaluminium hydride / CH₂Cl₂ / 0.5 h / -78 °C

3: 65 percent / ZnCl₂ / CH₂Cl₂ / 0.25 h / -20 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; sulfuric acid; diisobutylaluminium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; zinc(II) chloride; In dichloromethane;
DOI:10.1039/c39940001147

Reference yield:

: (2S,4S,5S)-4-Methoxy-6-(4-methoxy-benzyloxy)-5-methyl-hexane-1,2-diol

: 157811-04-6
{(2R,6S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / Et₃N, DMAP / CH₂Cl₂ / 14 h

2: 97 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

3: 91 percent / TBAF / tetrahydrofuran / 10 h / 25 °C

4: 1.) 1,3-dimethyl-3,4,5-tetrahydro-2(1H)-pyrimidinone, n-BuLi, 2.) H₂SO₄, 3.) TsOH, 4.) Et₃N, 1,8-diazabicyclo<5.4.0>undec-7-ene

5: 95 percent / diisobutylaluminium hydride / CH₂Cl₂ / 0.5 h / -78 °C

6: 65 percent / ZnCl₂ / CH₂Cl₂ / 0.25 h / -20 °C

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; sulfuric acid; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; zinc(II) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c39940001147