Technology Process of (R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane
There total 13 articles about (R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 25 ℃;
for 10h;
DOI:10.1039/c39940001147
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) (-)-β-methoxydiisopinocampheylborane, 3.) 3N aq. NaOH, 30percent aq. H2O2
2: 1.) n-BuLi, 3.) I2
3: K2CO3 / methanol / 4 h / Ambient temperature
4: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) THF, 0 deg C, 8 h
With
sodium hydroxide; n-butyllithium; dihydrogen peroxide; iodine; sodium hydride; potassium carbonate; (-)-B-methoxydiisopinocampheylborane;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 95 percent / CSA / CH2Cl2 / 18 h / Ambient temperature
2: 85 percent / Dibal-H / CH2Cl2 / 1 h / -78 °C
3: 1.) (-)-β-methoxydiisopinocampheylborane, 3.) 3N aq. NaOH, 30percent aq. H2O2
4: 1.) n-BuLi, 3.) I2
5: K2CO3 / methanol / 4 h / Ambient temperature
6: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) THF, 0 deg C, 8 h
With
sodium hydroxide; n-butyllithium; camphor-10-sulfonic acid; dihydrogen peroxide; iodine; sodium hydride; diisobutylaluminium hydride; potassium carbonate; (-)-B-methoxydiisopinocampheylborane;
In
methanol; dichloromethane;
