(R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane

Base Information

Chemical Name:(R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane
CAS No.:157758-29-7
Molecular Formula:C₁₆H₂₄O₄
Molecular Weight:280.364
Hs Code.:

Synonyms:(R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane

Suppliers and Price of (R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane

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Technology Process of (R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane

There total 13 articles about (R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 157758-39-9
Methanesulfonic acid (1S,3S,4S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-methoxy-5-(4-methoxy-benzyloxy)-4-methyl-pentyl ester

: 157758-29-7
(R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 10h;
DOI:10.1039/c39940001147

Reference yield:

: 132969-60-9
(2S)-3-[(4-methoxybenzyl)oxy]-2-methylpropanal

: 157758-29-7
(R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) (-)-β-methoxydiisopinocampheylborane, 3.) 3N aq. NaOH, 30percent aq. H2O2

2: 1.) n-BuLi, 3.) I₂

3: K₂CO₃ / methanol / 4 h / Ambient temperature

4: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) THF, 0 deg C, 8 h

With sodium hydroxide; n-butyllithium; dihydrogen peroxide; iodine; sodium hydride; potassium carbonate; (-)-B-methoxydiisopinocampheylborane; In methanol;

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 157758-29-7
(R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / CSA / CH₂Cl₂ / 18 h / Ambient temperature

2: 85 percent / Dibal-H / CH₂Cl₂ / 1 h / -78 °C

3: 1.) (-)-β-methoxydiisopinocampheylborane, 3.) 3N aq. NaOH, 30percent aq. H2O2

4: 1.) n-BuLi, 3.) I₂

5: K₂CO₃ / methanol / 4 h / Ambient temperature

6: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) THF, 0 deg C, 8 h

With sodium hydroxide; n-butyllithium; camphor-10-sulfonic acid; dihydrogen peroxide; iodine; sodium hydride; diisobutylaluminium hydride; potassium carbonate; (-)-B-methoxydiisopinocampheylborane; In methanol; dichloromethane;