1,1-dimethylethyl [2-({[4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl]carbonyl}amino)-3-phenylpropyl]carbamate

Base Information

Chemical Name:1,1-dimethylethyl [2-({[4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl]carbonyl}amino)-3-phenylpropyl]carbamate
CAS No.:1067613-46-0
Molecular Formula:C₂₅H₂₈ClFN₄O₃
Molecular Weight:486.974
Hs Code.:

Synonyms:1,1-dimethylethyl [2-({[4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl]carbonyl}amino)-3-phenylpropyl]carbamate

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Chemical Property of 1,1-dimethylethyl [2-({[4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl]carbonyl}amino)-3-phenylpropyl]carbamate

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Technology Process of 1,1-dimethylethyl [2-({[4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl]carbonyl}amino)-3-phenylpropyl]carbamate

There total 3 articles about 1,1-dimethylethyl [2-({[4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl]carbonyl}amino)-3-phenylpropyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 153556-42-4
4-bromo-3-fluorobenzoic acid

: 1067613-46-0
1,1-dimethylethyl [2-({[4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl]carbonyl}amino)-3-phenylpropyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 80 °C / Sealed tube

1.2: pH 3

2.1: N-chloro-succinimide / tetrahydrofuran / 1 h / 70 °C / Sealed tube

2.2: pH 3

3.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 1 h

With N-chloro-succinimide; potassium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1044851-42-4
1,1-dimethylethyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]carbamate

: 1067613-46-0
1,1-dimethylethyl [2-({[4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl]carbonyl}amino)-3-phenylpropyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / tetrahydrofuran; methanol / 12 h / 50 °C / Sealed tube

2: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 1 h

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; hydrazine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1067613-13-1
3-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzoic acid

: 1067613-46-0
1,1-dimethylethyl [2-({[4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl]carbonyl}amino)-3-phenylpropyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / tetrahydrofuran / 1 h / 70 °C / Sealed tube

1.2: pH 3

2.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 1 h

With N-chloro-succinimide; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; dichloromethane;