methyl 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate

Base Information

• Chemical Name: methyl 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate
• CAS No.: 129799-44-6
• Molecular Formula: C₃₀H₃₈N₂O₈
• Molecular Weight: 554.64

Synonyms:methyl 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate

Chemical Property of methyl 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate

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Technology Process of methyl 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate

There total 9 articles about methyl 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylic acid (129799-46-8) + methyl iodide (74-88-4) → methyl 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate (129799-44-6)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; for 12h; Ambient temperature;

DOI:10.1248/cpb.42.551

Reference yield:

methyl 4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate dihydrochloride + 3-dimethoxy-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid chloride → methyl 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate (129799-44-6)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

methyl 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl) piperazine-2carboxylate + methyl 1-(2,3-dimethoxy-6,7-dihydro-5H-benzo-cyclohepten-8-ylcarbonyl}piperazine-2-carboxylate hydrochloride + 5-(chloromethyl)-1,2,3-trimethoxybenzene (3840-30-0) → methyl 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate (129799-44-6)

Guidance literature:

With potassium carbonate; In acetonitrile;

upstream raw materials:

1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylic acid

methyl iodide

ethyl 2-piperazinecarboxylate

ethyl 4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate

Downstream raw materials:

1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylic acid

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