macrocycle Lys-NMe-D-Phe-Phe-(Cbz)Lys-Leu

Base Information

Chemical Name:macrocycle Lys-NMe-D-Phe-Phe-(Cbz)Lys-Leu
CAS No.:1321841-96-6
Molecular Formula:C₄₅H₆₁N₇O₇
Molecular Weight:812.022
Hs Code.:

Synonyms:macrocycle Lys-NMe-D-Phe-Phe-(Cbz)Lys-Leu

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Chemical Property of macrocycle Lys-NMe-D-Phe-Phe-(Cbz)Lys-Leu

Chemical Property:

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Technology Process of macrocycle Lys-NMe-D-Phe-Phe-(Cbz)Lys-Leu

There total 5 articles about macrocycle Lys-NMe-D-Phe-Phe-(Cbz)Lys-Leu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1321841-94-4
macrocycle (Boc)Lys-NMe-D-Phe-Phe-(Cbz)Lys-Leu

: 1321841-96-6
macrocycle Lys-NMe-D-Phe-Phe-(Cbz)Lys-Leu

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2011.06.083

Reference yield:

: 86060-82-4,110990-07-3
Fmoc-Lys(Z)-OH

: 1321841-96-6
macrocycle Lys-NMe-D-Phe-Phe-(Cbz)Lys-Leu

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-formamide / solid phase reaction

1.2: solid phase reaction

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / dichloromethane; acetonitrile

3.1: trifluoroacetic acid / dichloromethane

With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.06.083

Reference yield:

: 35661-40-6
N-Fmoc L-Phe

: 1321841-96-6
macrocycle Lys-NMe-D-Phe-Phe-(Cbz)Lys-Leu

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-formamide / solid phase reaction

1.2: solid phase reaction

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / dichloromethane; acetonitrile

3.1: trifluoroacetic acid / dichloromethane

With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.06.083